Acaricidal Investigation Of Commiphora Swynnertonii (Burtt) Stem Bark Exudate

ABSTRACT

The present study was carried out to investigate acaricidal potencies of Commiphora swynnertonii (Burtt) stem bark exudate against ticks Rhepicephalus appendiculatus and evaluate its toxicity using mice and rats. Commiphora swynnertonii exudate was prepared in soap solution and evaluated against the R. appendiculatus using adult immersion test method (AIT). The percent mortality, Index of laying eggs and percentage hatching were determined at concentrations of 100, 90, 80, 70, 60, 50, 25 and 12.5 mg/ml. The acute and sub-acute toxicity was determined by oral administration of the exudates to mice and rats at 500, 1000, 3000 and 250, 500, 1000 mg/Kg body weight respectively as a single (14 days) and daily dosing (28days). Physiological, behavioral changes, hematology, relative internal organs weights, biochemical and histopathology were assayed. Results show that at concentration above 25mg/ml there was significant mortality (p