ABSTRACT
Background: Urinary tract infections (UTI) are among the most common bacterial infections affecting people worldwide. The misuse of antibiotics used to treat UTIs has led to the development of resistance among the major uropathogens in Ghana. The local antimicrobial resistance pattern among uropathogens to help empirical decision making is not known at the Eastern Regional Hospital, Koforidua.
Objective: This study examined the resistance pattern of uropathogenic bacteria over a five year period and associated factors among patients diagnosed with UTI at the EasternRegional Hospital, Koforidua.
Methods: A retrospective cross-sectional study design was used to review records of urine culture and sensitivity data to determine resistance patterns and associated factors among patients diagnosed with UTI at the Regional Hospital in Koforidua from 2014 to 2018.
Results: The prevalence of UTI was 20.3% among study subjects. Out of fourteen isolates assessed, Escherichia coli (42.98%), Klebsiella spp (29.97%) and Citrobacter spp (12.51%) were the most dominant uropathogens accounting for UTI. Resistance to antibiotics was very high among uropathogens isolated with Ampicillin (90.8%), Co-trimoxazole (89.7%) and Tetracycline (88.6%) being the most resistant antibiotics and Amikacin (8.7%), Nitrofurantoin (35.9%) and Ciprofloxacin (37.5%) being the least resistant. Increasing age (AOR=2.53 CI=1.83, 3.47) and In-patient (AOR=1.26, CI=1.05, 1.53) are associated with ciprofloxacin resistance.
Conclusion: This study showed that uropathogens responsible for UTI showed generally high resistance to the commonly prescribed antibiotics with few exceptions. These results could help inform empirical treatment decisions for Urinary Tract Infections locally and also contribute to AMR surveillance in general.
GBADAGO, F (2021). ANTIMICROBIAL RESISTANCE PATTERNS AND ASSOCIATED FACTORS AMONG PATIENTS DIAGNOSED WITH URINARY TRACT INFECTION AT THE EASTERN REGIONAL HOSPITAL IN KOFORIDUA: A FIVE-YEAR RETROSPECTIVE STUD. Afribary. Retrieved from https://tracking.afribary.com/works/antimicrobial-resistance-patterns-and-associated-factors-among-patients-diagnosed-with-urinary-tract-infection-at-the-eastern-regional-hospital-in-koforidua-a-five-year-retrospective-stud
GBADAGO, FRED "ANTIMICROBIAL RESISTANCE PATTERNS AND ASSOCIATED FACTORS AMONG PATIENTS DIAGNOSED WITH URINARY TRACT INFECTION AT THE EASTERN REGIONAL HOSPITAL IN KOFORIDUA: A FIVE-YEAR RETROSPECTIVE STUD" Afribary. Afribary, 08 Mar. 2021, https://tracking.afribary.com/works/antimicrobial-resistance-patterns-and-associated-factors-among-patients-diagnosed-with-urinary-tract-infection-at-the-eastern-regional-hospital-in-koforidua-a-five-year-retrospective-stud. Accessed 24 Nov. 2024.
GBADAGO, FRED . "ANTIMICROBIAL RESISTANCE PATTERNS AND ASSOCIATED FACTORS AMONG PATIENTS DIAGNOSED WITH URINARY TRACT INFECTION AT THE EASTERN REGIONAL HOSPITAL IN KOFORIDUA: A FIVE-YEAR RETROSPECTIVE STUD". Afribary, Afribary, 08 Mar. 2021. Web. 24 Nov. 2024. < https://tracking.afribary.com/works/antimicrobial-resistance-patterns-and-associated-factors-among-patients-diagnosed-with-urinary-tract-infection-at-the-eastern-regional-hospital-in-koforidua-a-five-year-retrospective-stud >.
GBADAGO, FRED . "ANTIMICROBIAL RESISTANCE PATTERNS AND ASSOCIATED FACTORS AMONG PATIENTS DIAGNOSED WITH URINARY TRACT INFECTION AT THE EASTERN REGIONAL HOSPITAL IN KOFORIDUA: A FIVE-YEAR RETROSPECTIVE STUD" Afribary (2021). Accessed November 24, 2024. https://tracking.afribary.com/works/antimicrobial-resistance-patterns-and-associated-factors-among-patients-diagnosed-with-urinary-tract-infection-at-the-eastern-regional-hospital-in-koforidua-a-five-year-retrospective-stud