Assessment of Effective Use of Anti-Epileptic Drug Therapy Among Patients at Kagando Hospital

TABLE OF CONTENTS

DECLARATION ............................................................................................................................... i

ACKNOWLEDGEMENT ................................................................................................................ ii

DEDICATION ................................................................................................................................. iii

TABLE OF CONTENTS ................................................................................................................ iv

ABBREVIATIONS ........................................................................................................................ vii

CHAPTER ONE .............................................................................................................................. 1

1.0 INTRODUCTION ............................................................................................................... 1

1.1.0 Background ............................................................................................................................. 1

1.2.0Problem statement. .................................................................................................................. 2

1.3.0Research questions ................................................................................................................... 3

1.4.00bjectives ................................................................................................................................ 3

1.4.1 General objectives ................................................................................................................... 3

1.4.2 Specific objectives. ................................................................................................................. 4

1.5.0Justification of the study .......................................................................................................... 4

1.6.0Significance of the study ......................................................................................................... 5

CHAPTER TWO ......................................................................................................................... 6

2.0 LITERATURE REVIEW ...................................................................................................... 6

2.1.0 Causes and symptoms of seizures ....................................................................................... 6

2.2.0 Epilepsy and genes ............................................................................................................. 7

2.3.0 Epilepsy and anti-epileptic drugs ........................................................................................ 7

2.4.0Epilepsy in Africa ................................................................................................................ 9

2.5.0 Adherence to epileptic therapy ........................................................................................... 9

CHAPTER THREE ............................................................................................................... 11

3.0 METHODOLOGY AND MATERIALS ......................................................................... ll

3.1.0 Study design .................................................................................................................. 11

3.2.0 Study area ..................................................................................................................... 11

3.3.0 Study population ........................................................................................................... 11

3.4.0 Selection criteria ........................................................................................................... 11

3.~.0 Population and sampling ............................................................................................... 12

3.6.0 Sampling procedure ...................................................................................................... 12

3.7.0 Tools and data collection methods ................................................................................ 12

3.8.0 Data collection .............................................................................................................. 12

3.9.0 Data analysis ................................................................................................................. 12

3.10.0 Ethical considerations ................................................................................................. 13

iv

3.10.1 Limitation of the study ................................................................................................ 13

CHAPTER FOUR ................................................................................................................. 14

4.0 RESULTS ........................................................................................................................ 14

4.1.0 DEMORGRAPHIC DATA .......................................................................................... 14

TABLE !.Showing the demographic distribution and social economic filctors of the

participants ............................................................................................................................. 15

4.2.0 ASSESSMENT OF THE PATIENT/PHYSICIAN RELATIONSHIP AND

PATJENT/DISPENSER OR PHARMACIST RELATIONSHIP ......................................... 16

TABLE 2. Showing patient/physician relationship and patient/dispenser questions and advice

offered to patients .................................................................................................................. 16

4.3.0 THE PERCENTAGE PROPORTION OF ADHERENT PATIENTS TO

THEIR ANTI-EPILEPTIC MEDICATION .......................................................................... 16

TABLE 3, showing the percentage proportion of adherent patients ...................................... 17

4.4.0 THE DETAILED ACCOUNT OF THE NON-ADHERENT PATIENTS (TIME

FACTOR AND THE REASONS FOR NON-ADHERENCE) ............................................. 17

TABLE 4; showing the detailed account of non-adherent patients ....................................... 17

GRAPH 1 ............................................................................................................................... 18

4.6.0 FACTORS AFFECTING ADHERENCE (N=38) ....................................................... 19

4.7.0 PATIENT'S ATTITUDE TOWARDS HIS/HER ABILITY TO COMPLY AND

WHETHER HE/SHE BELIEVES THERAPY IS BENEFICIAL. ........................................ 19

TABLES, showing the demographic and social economic factors among the non-adherent

patients ................................................................................................................................... 20

Table 6, showing physician factors and dispenser questions and advise to patients who did not

adhere ..................................................................................................................................... 21

CHAPTER FIVE ................................................................................................................... 22

5.1.0 DISCUSSION, CONCLUSIONS AND RECOMMENDATIONS................................. 22

5.1.1 DISCUSSION ............................................................................................................. 22

5.1.2CONCLUSION .............................................................................................................. 23

5.1.3 RECOMMENDATIONS .............................................................................................. 23

REFERENCES . ..................................................................................................................... 24

Appendix 1: ............................................................................................................................ 25

QUESTIONNAIRE ............................................................................................................... 25

Appe~dix l 1 ............................................................................................................................ 28

RESEARCH BUDGET ......................................................................................................... 28

Appendix II! ......................................................................................................................... 28

TIME FRAME ....................................................................................................................... 28

Appendix IV .......................................................................................................................... 29