Abstract
Background: Polycystic ovary syndrome is a heterogeneous endocrine disorder
which affects 5–15% of the general population, depending on the ethnicity and the
applied classification system, Polycystic ovary syndrome (PCOS) is the most
common endocrine disorder in women of reproductive age It is characterized by
polycystic ovaries, oligo-amenorrhea, and hyperandrogenism.
Objective: The aim of this study is to assess testosterone, HDL-c and LDL-c in
patients with polycystic ovary syndrome (PCO).
Methods: This cross sectional study was conducted at Alsir Abu Hassan center for
fertility in Khartoum State, the study carried out on a total sample of 100 females
including 50 females with polycystic ovary syndrome patients as case and 50 healthy
females as control group. Serum testosterone levels was estimated using Enzyme
linked immune sorbent assay technique and serum HDL-c, LDL-c level was estimated
using spectrophotometer biosystem-310 . Data analyzed using SPSS software
program version20.
Results: This study showed that the levels of testosterone was significantly increased
with (p-value 0.000); while there was insignificant elevation in level of HDL-c, LDLc
with ( p-value HDL-c(0.412)and p-value LDL-c(0.957)) in polycystic ovary
syndrome patients compared to control group. When comparing polycystic ovary
syndrome patients according to menstrual regulation, infertility, duration , family
history, cosmetics and take of medication the study showed that there was significant
increase in testosterone across menstrual regularity ,duration, infertility , family
history, cosmetics and take of medication with (p-value 0.000) , and insignificant
deference in HDL-c LDL-c across menstrual regularity with (p-value 0.130)(p-value
0.207) infertility with (p-value 0.208) (p-value 0.254),, family history with (p-value
0.708)(p-value 0.254), cosmetics with (p-value 0.159)(p-value 0.320) and take of
medication with (p-value 0.571)
(p-value 0.574).
There was no correlation between testosterone levels with age, and body mass index
(R -0.177 P. value 0.218, R -0.554 P. value 0.708) and negative correlation with
duration (R -0.562 P. value 0.002) respectively. Also, there was no correlation
between HDL-c with duration, body mass index and with age (R 0.011 P. value
0.756** R -0.06 P. value 0.679**R -0.246 P. value 0.085) respectively and no
correlation between LDL-c with duration ,body mass index with (R 0.460 P. value
0.756** R 0.294 P. value 0.38) , and weak positive correlation with age with ( R
0.321 P. value 0.023).
Conclusion: From the results and finding of this study, it is concluded that:
The serum levels of testosterone are higher in PCOs female patients, and there are
observed change in HDL-c and LDL-c concentration PCOs female patients.
No correlations were found between BMI and age and serum levels of testosterone
HDL-c and LDL-c . No correlations were found between duration and serum levels
of HDL-c and LDL-c ,and negative correlation between duration and testosterone level.
Ali, M (2021). Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome. Afribary. Retrieved from https://tracking.afribary.com/works/assessment-of-testosterone-ldl-and-hdl-cholesterol-among-females-with-polycystic-ovary-syndrome
Ali, Mohammed "Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome" Afribary. Afribary, 21 May. 2021, https://tracking.afribary.com/works/assessment-of-testosterone-ldl-and-hdl-cholesterol-among-females-with-polycystic-ovary-syndrome. Accessed 06 Nov. 2024.
Ali, Mohammed . "Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome". Afribary, Afribary, 21 May. 2021. Web. 06 Nov. 2024. < https://tracking.afribary.com/works/assessment-of-testosterone-ldl-and-hdl-cholesterol-among-females-with-polycystic-ovary-syndrome >.
Ali, Mohammed . "Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome" Afribary (2021). Accessed November 06, 2024. https://tracking.afribary.com/works/assessment-of-testosterone-ldl-and-hdl-cholesterol-among-females-with-polycystic-ovary-syndrome