Associiation Between Vitamin D and Renal Function Among Ghanaian HIV/AIDS Patients

BERNICE ACKOM 67 PAGES (14331 WORDS) Pathology Thesis

A gkcaB r nuo d ehT erp v nela ce of H VI noma g anahG i na y htuo ar ng se morf 4.2 % ot .3 5 .% aM ny d shtae fo H VI stneitap era c desua by c snoitacilpmo ekil laner dna oidrac v ralucsa sid ae .ses dipaR noitacilper of HIV hcihw si derovaf by in rc e desa ox itadi ev st sser dna eht kcatta fo itcaer ev ox evitadi eiceps s )SOR( no eht 4DC + T-c slle era ht e rojam esuac s fo +4DC T- llec ped l noite ni HI /V AI SD p stneita . Effe evitc ucric l nita g oitna x tnadi dna slarenim am y lp ay tnatropmi elor ni niliatruc g eht d uoiretele s eff tce fo .SOR HIV- detcefni pe snosr evah a ih gh elaverp n ec fo vi nimat D neicifed cy an d usni f neicif cy. emoS larivorteritna rd ugs are onk wn ot fretni e er htiw nimativ D msilobatem c isua ng neicifed cy of nimativ D. ,suhT eht ekatni fo mi stneirtunorc nidulcni g vi nimat D si ruocne a deg . stneirtunorciM ekil nimativ D nehw nekat ni ih g reh sesod nac dael ot hyp re c cla aime . Hyp re c aimecla lausu ly c setubirtno ot muiclac de stisop in eht ndik ey c ua s ni g ndik ey ,senots ndik ey mad ag dna e lautneve ly k ndi ey f .erulia G ne e A lar im: ihT uts s dy ta demia ed et ninimr g mativ mures eht i hsilbatse dna slevel D n ing htiw noitaicossa sti ndik ey f u oma noitcn ng naianahG HI /V AI tap SD i ro htiw TRAAH no stne nimativ tuohtiw stnemelppus ygolodohteM : sihT uts dy saw a ssorc -se lanoitc uts dy ac r deir tuo ta t eh F sreve tinU fo oK r el -B u T ihcae ng atipsoH l dna eht lacimehC olohtaP gy eD p tnemtra fo eht elloC ge fo H htlae eicS n ,ec isrevinU ty fo ahG n .a T ow derdnuh napicitrap ts demrifnoc ot eb itisop ve fo HIV-1 dna ro HIV-2 erew detceles r modna ly morf eht F ve e sr tinU fo lroK e-Bu Tea ihc ng .latipsoH stneitaP nikat g H AA RT na d nimativ tnemelppus f ro erom naht six om n sht erew 001 edam pu fo )%03(03 selam dna 07 )%07( elamef s . iix F fi ty stneitap no AAH RT dna nimativ pus p tnemel rof ssel naht six om n sht stneitap desirpmoc fo 71 %43( ) selam dna 33 6( 6 )% amef l .se stneitaP ton no htob AAH RT dna nimativ tnemelppus saw ,05 edam pu fo 41 2( 8 )% m sela dna 63 7( 2 )% f ame l .se B dool selpmas atbo i den ew re analys de rof 2 5 hy ord xy ,3D nimativ cr ae a muiclac mures ,eninit n .nimubla d stluseR ehT naem sy cilots doolb erusserp S( B )P fo stneitap pmoc dera ma ong eht eerht g spuor w sa lacitsitats ly sig ifin c tna (p < .)50.0 vewoH er, ht e naem cilotsaid doolb p erusser (DB )P dna ob dy ssam edni x (BMI) aw s ton lacitsitats ly sig tnacifin ni eht p stneita nikat g H AA RT and imativ n tnemelppus rof erom naht six shtnom , stneitap ta nik g AAH RT dna nimativ tnemelppus rof ssel aht n is x AAH htob no ton esoht dna shtnom RT tiv dna a .)50.0 >p( tnemelppus nim ehT naem etamitse d raluremolG oitartlif n ,setar nimubla , lac c ,mui ninitaerc e dna 25 hydroxy nimativ D level s erew ton lacitsitats ly si tnacifing ni eht 3 tac eg ro i se fo stneitap deiduts p( > .)50.0 52 hy ord xy nimativ D le slev ew re wol ( 51< ng )lm/ ni stneitap no AAH RT dna nimativ nemelppus t rof eht tac eg seiro om( re naht xis shtnom , ssel aht n six om n sht dna on t no b hto AAH RT dna imativ n .)tnemelppus ehT aem n eGFR aw s > 60 mL nim/ / 37.1 m2 rof tuoba 07 % of eht p stneita no HAART dna nimativ tnemelppus rof erom naht is x ,shtnom ssel naht is x shtnom a dn stneitap ton no htob AAH RT ativ dna us nim p .tnemelp L D nimativ wo ew slevel r dnuof e a ssorc suoirav eht age spuorg . erehT saw on roc r noitale neewteb 52 hyd or xy tiv a nim D dna ,eninitaerc Ge F ,R nimubla dna muiclac fo eht stneitap on AAH RT dna nimativ melppus e tn rof rom e naht is x ,shtnom ssel naht is x shtnom AAH htob no ton stneitap dna RT us nimativ dna p .tnemelp oisulcnoC n Long ex erusop ot mativ in D id d ton c esua sti i cn esaer d level s ni ic r taluc i no dna id d ton r le ay any esrevda ef tcef no dik ney noitcnuf ni aianahG n H /VI AI SD stneitap re viec ing htob itna r larivorte and vitamin supplements.