Atherogenic Lipids Profile among Sudanese Females with Skin Tags in Khartoum State

Abstract

Skin tag is one of the most common skin disorders that affect different populations and it associate with atherogenic lipid profile, dyslipidemia, insulin resistance, hypertension and atherosclerosis. This case control study was done in Khartoum state during March to December 2017 among Sudanese females with skin tags to evaluate the relationship between skin tags and lipids.

Eighty Sudanese females were included in this study (40 with skin tags were selected as test group and 40 without skin tags as control group ( age was matched)), blood specimen was collected from both groups and cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol were analyzed spectrophotometrically; and BMI, LDL-C/HDL-C ratio and cholesterol/ HDL-C ratio were calculated.

Statistical analysis was done by using SPSS computer program. The study results revealed that there was significant elevation of cholesterol, LDL-C, cholesterol/ HDL-C ratio, LDL-C/HDL-C ratio and BMI with P. value (0.003), (0.024), (0.000), (0.000) and (0.000) respectively. The means± SD for skin tag group were (186.98± 31.79), (122.88± 31.29), (4.12± 1.12), (2.71± 0.91), (30.72± 5.11) respectively while in control group were (165.40± 31.52), (107.05± 30.29), (3.08± 0.88), (2.01± 0.76), (25.61± 4.98) respectively.

The result showed a significant decrease in HDL-C with (P. value 0.003), mean ±SD was (47.62± 11.24) in females with skin tags and (56.60±14.75) in control group. The results showed no correlation between BMI and cholesterol (r= 0.052, p. value 0.752), and no correlation between BMI and LDL-C (r= 0.038, p. value 0.817), while there is a significant negative correlation between BMI and HDL-C (r= -0.42, p. value= 0.006). In conclusion: The study showed that skin tags are related to dyslipidemia and obesity.