Abstract/Overview
Resistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, FcεRI and FcεRII/CD23; however, its functional significance requires further characterization in humans. We previously reported that increased levels of CD23+ B cells correlate with resistance to schistosomiasis in hyper-exposed populations and sought to define their potential function and relationship with IgE. We found that CD23+ B cells are a heterogeneous cell population with functional and phenotypic differences. Circulating CD23+ B cells are uniquely activated in schistosomiasis and express the CD23b isoform and CXCR5, the homing receptor for lymphoid follicles. High CXCR5 expression by CD23+ B cells was associated with the capacity to home to cognate ligand, CXCL13. CD23-bound IgE cross-linking increased surface expression of CXCR5 suggesting that CD23+ B cells home directly into the lymphoid follicles upon antigen capture. As human schistosomiasis is an intravascular parasitic infection associated with a high antigenic burden in the blood, circulating CD23+ B cells may play a role in capture and shuttling of antigens directly to splenic follicles, highlighting a new role for circulating B cells. This function likely plays an important role in the development of protective immunity to infection with schistosomes
O., O (2024). CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells. Afribary. Retrieved from https://tracking.afribary.com/works/cd23b-isoform-expression-in-human-schistosomiasis-identifies-a-novel-subset-of-activated-b-cells
O., Onguru "CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells" Afribary. Afribary, 16 Jul. 2024, https://tracking.afribary.com/works/cd23b-isoform-expression-in-human-schistosomiasis-identifies-a-novel-subset-of-activated-b-cells. Accessed 22 Dec. 2024.
O., Onguru . "CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells". Afribary, Afribary, 16 Jul. 2024. Web. 22 Dec. 2024. < https://tracking.afribary.com/works/cd23b-isoform-expression-in-human-schistosomiasis-identifies-a-novel-subset-of-activated-b-cells >.
O., Onguru . "CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells" Afribary (2024). Accessed December 22, 2024. https://tracking.afribary.com/works/cd23b-isoform-expression-in-human-schistosomiasis-identifies-a-novel-subset-of-activated-b-cells