Clinicopathological Findings Of Retinoblastoma: A 10-Year Experience From A Tertiary Hospital In Kampala, Uganda

Abstract

*is was a cross-sectional analytical study which involved a

total of 234 eyeball surgical specimens from 214 patients

with histological diagnosis of RB at Mulago National Referral

Hospital (MNH) in Kampala, Uganda, between 2006

and 2015. *e formalin-fixed embedded paraffin (FFEP)

tissue blocks were retrieved and retrospectively studied at

Makerere pathology laboratory. Fourteen (5.6%) cases were

excluded from the study either because of missing tissue

blocks or being spoiled by insects. For every eyeball specimen

included for histological evaluation, two serial sections

were made at a thickness of 3 microns, and each section was

stained using standard Harris’ haematoxylin and eosin

(H&E) stains. For pathological staging, TNMversion 8 of the

American Joint Committee on Cancer (AJCC) of 2017 was

applied (Table 1).

Data generated were collected using a structured data

collection form, and statistical analysis was done using SPSS

16.0 version (SAS Institute, Cary, NC 2010) software. Statistical

association between continuous and categorical

variables was computed using Fisher’s exact test and Pearson

chi-square (χ2) test, respectively. P < 0.05 was considered

statistically significant.

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