ABSTRACT The purpose of this study was to develop a reversed-phase chromatographic method for the quantification of atovaquone, with a view to establish the disposition of atovaquone in selected Nigerians, thereby validating the method developed. However, the parameters involved in the HPLC method developed, included the use of an appropriate internal standard, pyrimethamine. In the developmental phase of method development, the following parameters were established an appropriate internal st...
ABSTRACT There is dearth of scientific information on the effects of Hybanthus enneaspermus (HE) and Parquetina nigrescens (PN) on female reproduction, pregnancy and its outcome. Yet, these two medicinal plants remain the first line of medicinal plants commonly used by Traditional Birth Attendants in care of women before, during and after pregnancy in South-west Nigeria. The effect of aqueous leaf extract of Hybanthus enneaspermus (HEaq) and Parquetina nigrescens (PNaq) on female reproductio...
ABSTRACT This experiment is designed to investigate the effects of Kigelia africana fruit extract (KAFE) on cisplatin-induced testicular damage in Sprague-Dawley rats. 280 male Sprague-Dawley rats weighing 200 + 20 g were used for the experiments which were run in replicates of 140 rats per set for the purpose of reproducibility of results. The experiments were categorised into short term (28 days) and long term durations (56 days). Mature and ripe fruit of Kigelia africana were obtained and ...
ABSTRACT Benign hyperplasia and Carcinoma of prostate are pro static disorders commonly found in aging sales. These disorders are reported to be less common amongst Nigerians, though there has been no concrete pathophysiological evidence to support this observation. The exact aetiology of these disorders has not been resolved, but some factors have been identified as being contributory to their development. Amongst these factors are androgenic hormonal control and the influence of some trace-...
ABSTRACT A comprehensive review of the origin of cowpea, (Vigna unquiculata) its place in the diet of the people of West Merion and in particular Nigeria, its nutritive value and the inherent anti-nutritional factors, together with the biological mechanisms affecting protein digestion is given. The search revealed that there are about 39 varieties of cowpea in circulation within West Africa, of which 4 with average protein content of 26.7 per cent) are major in the diet of the people. These a...
Abstract Background: Vaccine preventable diseases still account for a large proportion of childhood morbidity and mortality in children less than five of age. The decline in immunization coverage over the years has worsened this resulting in the re-emergence of hitherto controlled infections such as diphtheria. Objective: To review the presentation, management and outcome of cases of probable diphtheria seen at the children emergency centre at the Lagos University Teaching Hospital. Metho...
ABSTRACT Background: Retinoblastoma is the most common intraocular childhood malignancy. Its management is, however, not without challenges especially in a developing country like Nigeria. This study sought to present the clinical profile and treatment outcome of patients with retinoblastoma managed in a Nigerian tertiary eye care facility highlighting the challenges with a view to improving the management of the disease. Materials and Methods: Aretrospective, single-institution, and institu...
ABSTRACT Context: Most cases of gut malrotation are diagnosed in the 1st year of life, but in minority of cases, the patient becomes symptomatic only in adolescence or adulthood. Aims: The aim of this study was to remind physicians to include intestinal malrotation in the differential diagnosis of children who present with recurrent abdominal pain, especially when it is associated with vomiting and other gastrointestinal symptoms. Settings and Design: This was an audit of the older children ...
Table of contents Acknowledgement vii Declaration viii Abstract ix Chapter 1: Introduction and Background of the Study 1.1 Introduction 1 1.2 Background Overview of Strategic Planning Process in the Public Service of Namibia 1 1.3 Benefits of Strategic Planning 3 1.4 Statement of the Research Problem 3 1.5 Research Aim 4 1.6 Research Objectives 4 1.7 Research Questions 5 1.8 Significance of the Study 5 1.9 Structure of the Dissertation 6 1.10 Conclusion 6 Chapter 2: Literature Review 2.1 Intr...
ABSTRACT Quarry mining produces substantial dust amounts bearing an adverse effect on human health in several ways, mainly the respiratory system. Even though employers are obligated to protect their employees from occupational hazards, the quarry mining industry in Namibia has failed to honour that obligation. This study investigated quarry workers and the surrounding community’s exposure to dust as well as their risk of getting chronic respiratory diseases in the Erongo region of Namibia....
ABSTRACT Delay is one of the major problems in Zimbabwe construction industry. Delays lead to many negative effects such as disputes between clients and contractors, increased cost, loss of productivity and revenue and termination of contract. The aim of this research was to investigate the challenges faced in construction project completions and find ways to minimize the project delays. A case study method was adopted for this research through primary data and secondary data. The data coll...
ABSTRACT Introduction Tuberculosis and diabetes mellitus are public health challenges globally. The World Health Organization (WHO) Global report on diabetes reiterated that diabetes is a well-known risk factor for tuberculosis (TB) and that diabetes is associated with poor tuberculosis treatment outcomes, while tuberculosis is linked with deteriorating glycemic control. Namibia is among the top 30 high TB burden countries in the world (WHO, 2016) and added to that is the increasing prevalenc...
Abstract Zimbabwe has a generalized HIV epidemic. Since 2015, the national ART program has been rolling out a suite of differentiated models of care in line with the 2013 WHO guidelines. One of the common models adopted by the country is Multi-Month Scripting (MMS) for stable ART patients. Insufficient evidence exists in the country around the contribution of MMS to patient level ART outcomes, almost two years after it was rolled nationally. A retrospective cohort study was conducted at the ...
ABSTRACT Cardiovascular disease (CVD) causes 30% of deaths globally and has been reported to be on the increase in sub-Saharan Africa. Medications prescribed for CVD are largely an ongoing lifetime commitment aimed to preserve optimal heart function for as long as possible and as a result patients must adhere to their prescription. However, prescription adherence is influenced to a large part by prescription awareness, which is having information about prescribed drugs and their side effects ...
ABSTRACT Community Led Total Sanitation (CLTS) is an innovative way to achieve communities free from open defecation. Globally 1.1 billion people still practice open defecation and are at risk of diarrhea resulting in 2 million deaths annually. In Kenya 75.7 % population lack improved sanitation facilities and of these, 17.1% experience diarrhea cases. In Siaya diarrheal diseases are ranked third among the top ten diseases. Boro Division with latrine coverage 55%. However, there is still limi...