ABSTRACT The antidiabetic effect of aqueous stem bark extract of A. polycarpa (AP) in male ICR mice and its sub-chronic toxicity in Sprague-Dawley rats were investigated. The effect of AP (20 mg/kg, 100 mg/kg, and 500 mg/kg) on fasting blood glucose, serum triglyceride and total cholesterol levels were determined over a period of 4 weeks. An oral glucose tolerance test was also conducted over 150 min post-glucose load. Organ specific toxicity of AP (20 mg/kg, 100 mg/kg, and 500 mg/kg) in Spra...
ABSTRACT Background Nutritional anaemia in pregnancy still remains a problem of public health concern particularly in developing countries such as Ghana. The period of adolescence and pregnancy are both critical periods that place the individual at risk of developing nutrient deficiencies because of the rapid and increased demands in nutrients. Failure to meet the nutritional demands can affect the growth of the adolescent mother and that of the developing baby. Literature gaps exist in the ...
ABSTRACT Background: Iron deficiency anaemia is a consequence of suboptimal dietary iron intake or inefficient dietary iron absorption. Dialium guineense also known as black velvet tamarind (BVT) has a rich combination of both iron as well as vitamin C, coupled with low levels of antinutrients. Traditionally, the fruit pulp of BVT is used to treat iron deficiency anaemia in certain parts of the Ghana. The efficacy and effectiveness of these interventions however need a wider exploration. Aim:...
ABSTRACT Introduction: The concerns of possible resistance development by P. falciparum to most artemisinin-based combination therapies (ACT’s) is imminent and to an extent due to the non-uniform use of the ACT’s and drug pressure. This has necessitated the need to routinely monitor the drug efficacy every couple of years in all countries where malaria is endemic and studies on patterns of ACT prescription is also needed as an essential component to complement efficacy studies. Objective:...
ABSTRACT Periodic medical check-up (PMC) is important for early detection of risk factors associated with the development of diseases and prompt diagnosis of asymptomatic diseases. In Ghana, the daily activities of workers especially market workers are characterized by constant stress, long working hours, without being particularly mindful of their diet coupled with sedentary work life. This puts them at greater risk of developing several chronic diseases and their complication. However, stud...
ABSTRACT Introduction: Under – five mortality is a major problem in the world with millions of children not surviving to celebrate their fifth birthday. It is the fourth millennium development goal of which all countries were tasked to reduce by two thirds by the end of 2015. A further reduction to 25 or fewer deaths by 2030 as stipulated in the sustainable development goals. Ghana has made some strides towards achieving its target of reducing under – five mortality by two thirds but it ...
ABSTRACT In spite of several research efforts and therapeutic interventions, cancer remains a major public health burden across the globe. Cancer treatment is still confronted with challenges including drug resistance and many undesirable side effects. Chemotherapy, the standard cancer treatment is seriously challenged with a lot of shortcomings and hence finding an alternative source of potent anticancer agents is critical to combat the menace. Plant and other natural products have proven to...
ABSTRACT Background: The burden of mental and behavioral disorder has increased by 38% from 1990 to 2010 globally. In developing and under-developed income countries over 70% of this increase is due to mental disorder. In Ghana the prevalence of mental disorders has been estimated at 13% of the adult population. The purpose of the study was to examine caregivers’ perspectives on factors affecting medication non-adherence among mental health patients at the Pantang Psychiatric Hospital. Meth...
ABSTRACT Background: Hypertension is fast becoming a global public health issue especially in developing countries. However, very little is known about the disease and its associated risk factors in Ghana particularly among nurses. Objectives: The objective of this study was to assess the relationship between workrelated stress and hypertension among nurses at Ridge Regional Hospital, Accra, Ghana. Methods: Participants of this cross-sectional study included 208 nurses randomly selected from ...
ABSTRACT Background: Malaria and HIV represent the two most important public health problems of subSaharan Africa due to geographical overlap. Together, they are responsible for more than 4 million deaths a year. However, when HIV and malaria co-infect an individual, they drastically worsen the morbidity outcome for the person, increasing the odds of mortality than as single infections. In Ghana, there is paucity of data on the prevalence of this co-infection. This study determined the preval...
ABSTRACT Background: Unintended pregnancy prevalence in Ghana in married women is quoted at 37%. The Municipal Directorate of the Ho Municipality has also documented rising levels of induced abortion cases reporting for post abortion care. Recognizing that unintended pregnancies contribute to abortion and abortion related complications and their consequent contribution to increased maternal mortality ratio, the intension of the study is to determine the prevalence of unintended pregnancies in...
ABSTRACT Background: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination since 2000. Mass drug administration (MDA) started in the Ankobra community in 2000. Nevertheless, the microfilaremia rate is still up to 4.5 % in 2016. Noncompliance to MDA is an important factor that can sustain the persistence of the disease after the required five to six MDA rounds. This study was aimed at determining the noncompliance level and the reasons as well as the factors a...
ABSTRACT Emergency Contraceptive Pills (ECPs) are being used as regular contraception even though they should rather be used as a bridge to regular contraception. This could be achieved if pharmacy staff were to dispense ECPs such that clients would be informed and encouraged to access some form of regular contraception. This would involve good history taking as part of assessment prior to ECP provision by pharmacy staff. This study was aimed at assessing the dispensing practice of pharmacy s...
ABSTRACT Background: Hypertension is a common chronic non-communicable disease condition and as such takes a toll on the family and the community. Individuals with hypertension should take responsibility for their condition as this would improve blood pressure control. They should be motivated to adhere to medication, but this is not so. Hence, this study was done to assess how patients with hypertension attending Korle Bu Polyclinic managed their condition. Methods: This was a descriptive c...
ABSTRACT Background Postpartum family planning has the potential to reduce maternal and child morbidity and mortality. A short birth interval of less than two years is associated with adverse health effects for the mother and baby and the society as a whole. The aim of this study was to determine postpartum contraceptive prevalence among young mothers attending child welfare clinics in the Kwaebibirem District, Eastern Region, and explore factors that influence family planning uptake after de...