ABSTRACT The research work investigated the possible antifertility effect of the methanolic seed extract of Momordica charantia (Mc). The morphological changes following administration of the extract on testes of Sprague-Dawley rats (SD-rats) were assessed using stereological parameters, hormonal assay and measurement of testicular 'stress indicators Methodology: 670 adult male SD rats weighing 162452 g were used for the study, which was carried out in two phases of 40 weeks. There were 335 a...
ABSTRACT The overall aim of this research is to examine if the bark extract of Carica papaya would serve as a male contraceptive agent by determining the morphological response of the testes of Sprague-Dawley rats using histological and stereological parameters. Methodology: 60 adult (6-8 weeks old ) male Sprague-Dawley rats were used for this experiment which was conducted in 3 (three ) groups of 4 weeks, 8 weeks and the reversal group. In each group, rats were subdivided into another group ...
ABSTRACT BACKGROUND & OBJECTIVES: Results from past studies have provided evidence that cervical traction is of benefit in the treatment of neck pain, but there is no consensus among clinicians regarding the amount of traction weight to be employed during treatment that will reduce the side effects (vertigo, nausea, mild headache, blurred vision and migraine) associated with this modality, if not property administered. The study was designed to investigate the cardiovascular responses and sid...
ABSTRACT This experiment is designed to investigate the effects of Kigelia africana fruit extract (KAFE) on cisplatin-induced testicular damage in Sprague-Dawley rats. 280 male Sprague-Dawley rats weighing 200 + 20 g were used for the experiments which were run in replicates of 140 rats per set for the purpose of reproducibility of results. The experiments were categorised into short term (28 days) and long term durations (56 days). Mature and ripe fruit of Kigelia africana were obtained and ...
ABSTRACT This study is centered on the idealism of George Wilhelm Friedrich Hegel (1770 - 1831). It is anchored on a tripod of theme, problem and methodology. The theme of this study is Hegel‟s idealism. The problem is the status of women in Hegel‟s idealism, and the methodology is postmodernist phenomenological ontology. This tripod of theme, problem and methodology is further premised on the theoretical framework of Inter-subjectivity which offers us the opportunity to explore the polar...
ABSTRACT The prevalence of female infertility ranges from 7 to 28% depending on the age of the woman. Although the origin and frequency of infertility vary about 40 to 50% of the aetiology of infertility cases is as a result of female factors. Malaria and the treatment of malaria have being a major challenge for decades. A number of antimalarial drugs have been reported to have anti-fertility actions. Amodiaquine (AQ) is an anti-malarial drug and belongs to a class of drugs known as the 4-ami...
ABSTRACT Aims: The aims of the current study were to determine the prevalence of epidermal growth factor (EGFR) receptor in patients diagnosed with esophageal squamous cell carcinoma (ESCC) as well as assessing the correlation of overexpression of EGFR with age, gender and tumor grades of the cases. Study Design: This was a cross-sectional analytical study.
Background. Neglected tropical diseases continue to be one of the leading causes of morbidity and mortality in the developing world. Psychiatric patients are among groups at risk for parasitic infection although control and monitoring programs largely overlook this population. This study aimed at determining prevalence and factors associated with intestinal parasitic infection among patients admitted to a psychiatric facility. Method. The study followed cross-sectional design; all the residin...
Abstract The teleost digestive tract is simple and comprises the following parts: oropharyngeal cavity, oesophagus, stomach, intestine, rectum and anus. These organs are involved in the breakdown of ingested food macromolecules into small absorbable micromolecules. These small molecules are necessary for the maintenance, growth and energy needs of the body (Johnson, 1994; Junqueira and Carneiro, 2005). Besides processing food, some parts of the tract have evolved into organs of respiration (p...
ABSTRACT The embryotoxicity potentials of normal dosage regimens of chloroquine used for therapeutic purposes were assessed in this research. Accordingly, five dosage regimens ^ . 5 ,10;0 12.5 15;0 and 20;0®g/kg body weight)=0f chtorocjuine diphosphate were screened by the High Performance Liquid Chromatography (HPLC) method to select those, which will provide whole blood levels: m the (Sprague-Dawley) rats comparable to those achievable during therapeutic use. The dosages of 7.5, 10,0 and ...
ABSTRACT Exercise training enhances healthy brain function by regulating inflammation and oxidative stress and promotes the production of growth factors including brain-derived neurotrophic factor (BDNF). BDNF is essential for neuronal growth and survival in deleterious neurological conditions such as stroke, Parkinson’s and Alzheimer’s. Moreover, dietary nutrients in cocoa reduces oxidative stress and inflammation and may have a protective effect that affects the growth and survival of...
ABSTRACT Background: A detailed understanding of lumbar vertebral body morphometry and disc degeneration among Ghanaians is relevant for clinical and research purposes. Studies exist on how age and sex affect lumbar vertebral morphometry and disc degeneration among Caucasians, but there is paucity of similar information in African populations including Ghana. Association of weight and height with lumbar vertebral morphometry and disc degeneration remains inadequately investigated in both p...
ABSTRACT Introduction: Paracetamol (acetaminophen) is a widely used over-the-counter analgesic and antipyretic drug which is known to cause liver injuries in both humans and experimental animals when administered in overdose. Supratherapeutic dose of paracetamol results in accumulation of reactive oxygen species (ROS) which impairs the antioxidants defence mechanisms and thus, causes a redox imbalance. The resulting oxidative stress plays a vital role in paracetamol-induced hepatic toxicity....
ABSTRACT Four hundred and twenty-four consecutive umbilical cords of babies delivered at the Korle-Bu Teaching Hospital were studied along side some birth variables. This research was to first of all, find whether there were any possible correlations between any pair of variables. Secondly, whether any variant of the cord could have any clinical significance. The umbilical cord measurements were made using a tape measure and the results statistically analysed using the Statistical Package for...