Pharmacology Research Papers/Topics

Comparative study of aminosidine, etophamide and nimorazole, alone or in combination, in the treatment of intestinal amoebiasis in Kenya

Abstract/Overview 417 patients suffering from intestinal amoebiasis were randomly allocated to 6 different treatment groups in a controlled study in 3 District Hospitals in Kenya. The patients received either aminosidine (A), etophamide (E), nimorazole (N), or the combinations NA, NE, EA. Treatment in all cases was given twice daily for 5 days. Before and after treatment, rectosigmoidoscopy was done in each patient, and stool examination with characterization of invasive (IF) and non inva...

Lonchocarpus eriocalyx (Harms) Herb Extract for Use as Painkillers

Abstract/Overview Today, many herbal preparations are being prescribed as analgesics. In the past decade, there has been a resurgence of interest in traditional systems of medicine which has become a topic of global interest. Indeed, many important drugs in the market have been obtained directly/ indirectly from natural sources, for example: morphine, pilocarpine, quinine and artemisinin among others. Lonchocarpus eriocalyx (Harms) belongs to the family Fabaceae and is used traditionally ...

Metallo-Drugs as promising antibacterial agents and their modes of action

Abstract: Antibiotic resistance has been a growing worldwide public health issue. The World Health Organization (WHO) has stated that the search for new antibiotics is slow, while antibiotic resistance is growing. WHO has also declared that antibiotic resistance is one of the top 10 global public health threats facing humanity in the 21st century. Therefore, this review discusses the potential of metal-based drugs as antibacterial agents from the period of the early 2000s to date. The review...

Synthesis of mixed ligand ruthenium (II/III) complexes and their antibacterial evaluation on drug-resistant bacterial organisms

Abstract: The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species. The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility. Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complex...

Antibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolates

Abstract: Albizia anthelmintica is a medicinal plant belonging to the Fabaceae family. It is widely used by smallholder farmers and pastoralists to treat internal parasites in their livestock.This study aimed to determine the antibacterial and antioxidant potential of A. anthelmintica on pathogenic veterinary isolates. 100% hexane (He100), 100% chloroform (Ch100), 100% ethanol (E100), and 70% ethanol (E70) extracts of the roots and barks of A. anthelmintica were tested against four bacterial...

Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats

Abstract: Several medicinal plants have anti-diabetic properties and can be considered as an alternative therapy because of their actions which are like those of conventional antidiabetic drugs. In this study, we investigated Myrothamnus flabellifolius (MF) ethanol: water (70:30) extract for its possible anti-diabetic potential in streptozotocin-high energy diet (STZ-HED) induced type 2 diabetes mellitus (T2DM) rats and its possible mechanisms of action. Diabetic rats were divided into MF-50...

2_Ajibo et al analgesic cpds

The Antioxidant Analgesic activity of some Natural plants in Comparison to Acetaminophen 

Contribution of Indigenous Health Care Givers to -The Herbal Management of Febrile Illnesses in Rivers State, South-South, Nigeria

Introduction Malaria remains a major public health concern, especially in Africa, despite several years of research and billions of dollars spent on the development of drugs for the treatment of the disease. It is estimated that about 300 to 500 million cases of malaria occur globally every year, out of which 90% of the cases occur In Africa. It is also estimated that malaria is responsible for 1-2 million deaths annually in Africa (Toklohuimnnot, 2000). For over fifty years, the mainstay of ...

Phytosterols from Spondias mombin Linn with Antimycobacterial Activities

ABSTRACT The growing problems of tuberculosis have led to the search for new anti-Mtb agents from higher plants. The stem bark of Spondias mombin was evaluated for its in vitro activity against Mycobacterium tuberculosis (H37Rv strain). Bioassay-guided fractionation of the methanol extract was carried out by Vacuum Liquid Chromatography (VLC) on Silica gel (230-400 mesh) and purification was done using HPLC and TLC. In vitro antimycobacterial susceptibility was performed by a fluorometric mi...

In vitro Anti-mycobacteria Sensitivity and Kill-kinetics of Allium ascalonicum L. (whole plant) on Nontuberculous Mycobacteria Species

ABSTRACT Allium ascalonicum L. (Shallot) was one of the herbs repeatedly identified from the result of our ethnobotanical survey for the treatment of tuberculosis and nontuberculous mycobacteria diseases. It has been reported to show inhibitory potentials against several pathogens. This plant is also known to form part of the diet of many people across the world. In the quest for a more active and body-friendly therapeutic agents, extracts of Allium ascalonicum (whole plant) were screened aga...

Hypoglycemic Effect Hydroacetone Extracts of Treculia africana Decne Root and Stem Bark in Alloxan-Induced Diabetic Rats

ABSTRACT The main objective of this study was to compare the hypoglycemic activity of ethylacetate soluble portion of aqueous acetone extract of the root bark (EtOAcfr TARB) and stem (EtOAcfr TASB) back of Treculia africana Decne in diabetic rats and also to characterize the ultraviolent and infrared spectra of an isolated constituent. Oral administration of the EtOAcfr TARB reduced fasting blood glucose level by 28.6% in 144hrs and 15.9% at 240 hrs in alloxan (100 mg/kg) induced rat of five ...

Antimicrobial Activity of Garcinia kola (Heckel) Seed Extracts and Isolated Constituents Against Caries-causing Microorganisms

ABSTRACT Garcinia kola Heckel (Guttiferae) seed, has found use in folkloric medicine of Southern Nigeria for the treatment of toothache and prevention of dental caries. The crude ethanolic extract, chromatographic fractions and isolated constituents of Garcinia kola seed against clinical strains of dental-caries-causing and related microorganisms is being evaluated. Antimicrobial evaluations were done by testing different concentrations of the crude extract, vacuum liquid chromatographic (VL...

Nigerian Antimalarial ethnomedicine 2: Ethnobotanical surveys of herbal remedies used in the treatment of febrile illnesses in the middle belt of Nigeria

ABSTRACT An ethnobotanical survey was conducted among residents of Gboko and Kastina Ala local government areas in Benue state located in the middle belt of Nigeria.

Efficacy of herbal remedies used by herbalists in Oyo State Nigeria for treatment of Plasmodium falciparum infections a survey and an observation

ABSTRACT In the course of evaluating the contributions of phytomedicine to possible drug discovery of antimalarial drugs an ethnomedical survey of specialized children traditional clinics was done.

Do Frequent Antenatal Care Visits Ensure Access and Adherence to Intermittent Preventive Treatment of Malaria in Pregnancy in an Urban Hospital in South West Nigeria?

ABSTRACT The relationship of antenatal clinic (ANC) attendance and factors that could affect intermittent preventive treatment (IPT) uptake among 339 parturient women was examined. Respondents were enrolled over a period of three months in a secondary healthcare facility within 24 hours of delivery. Demographic details, delivery and antenatal history, insecticide treated net (ITN) use, and history of IPTp-Sulfadoxine-Pyrimethamine (SP) use in the index pregnancy were recorded. Finger and heel...


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