ABSTRACT. The interact ion of some water soluble vitamins -thiamine hydrochloride, riboflavin, nicotinarnide, pyridoxine hydrochloride and ascorbic acid with a xmntnlorillonite clay (Vecgum) has been investigated. The data obtained from the interactive studies fitted well on the isothermal equilibrium adsorption-tikc plots. Th3 results were analyzed using the Langmuir's equatim The Langmuirs p!3t yiclded reasonable linearity fiom which interactive constmts were ca!cc!atx!. The theoretical max...
ABSTRACT Modified and unmodified starches in current use have limited applications in pharmaceutical industries. Extending the modification beyond the existing level may increase their applicability in dosage forms design especially for gentamicin sulphate, a difficult to formulate broad spectrum antibiotic for oral administration. In this research, maize starch was chemically modified to three levels (primary, secondary and tertiary) using pre-determined optimal conditions and established mo...
ABSTRACT Background: Irrational use of medicines is a maJor problem worldwide. Studies conducted in several countries, including Uganda, indicate that more than 50% of all medicines used globally are used irrationally. Irrational use of medicines results in increased risk of adverse reactions, wastage of the scarce resources, and development of preventable resistance of organisms to commonly used antibiotics. To be able design appropriate interventions, there is need to carry out drug use stu...
ABSTRACT Background: Lidocaine, is an important anesthetic and anti-arrhythmic drug, widely used in medicine, at the same time a danger. The impurity 2, 6-xylidine is the starting material for its manufacture, degradation product of lidocaine on storage and metabolite when administered. This study seeks to identify 3 brands of lidocaine in Uganda Pharmacies, assess level of impurity and drug content by a comparative pharmacopoeial chemical analysis. Aim: To do a comparative pharmacopoeial an...
ABSTRACT Ocimum gratissimum and Ocimum suave belong to the family lamiaceae. Folkore medicine claims their use in many conditions. Leaves of 0 gratissimum and 0 suave were extracted in aqueous methanol by maceration, extract was filtered and evaporated using the rotary evaporator and dried to a constant weight in an oven. Phytochemical analysis was carried out to determine the active constituents and Quantification tests were carried out to obtain the amount of phytochmicals in each extract....
ABSTRACT. The purpose of this study was to evaluate the antibacterial activity, to determine the most efficiency extractive solvents and phytochemical profile of Hot water, Methanol alcohol and Lemon juice extract of Lawsonia inermis (henna) leaf. The plant attracted the attention of researchers because of its use as anti-infective agent. The oily and alcoholic extracts of the plant Lawsonia inermis dried powdered leaves were separately obtained by maceration, while the aqueous was obtained b...
ABSTRACT The Ugandan government has experimented with various supply chain models for delivery of essential drugs and supplies. In 20 I 0, the dual pull-push system was adopted; however drug stock outs are still a common occurrence in health facilities. This study on availability of essential medicines during the dual Pull-Push system in Kaliro District was undertaken; this was to be used as an indirect or direct indicator of availability of essential drugs and medical supplies during the dua...
ABSTRACT Background Despite the fact that herbal medicines are used by 80% of the World's population (WHO, 2002) and are the main source of health care in the rural communities and the most preferred form of treatment of HIV-related symptoms (Orisatoki and Oguntibeju, 20 I 0), less than I 0% of herbal products in the world market are tru ly standardized to a known active and/or toxic components (Winston et al. , 2007). Study carried out in Western Uganda reported 32.8% of same-day use of he...
ABSTRACT. Irrational prescribing of ARVs to HfV pregnant women is a major problem of poor control of HIV/AIDS all over the world. The researcher assessed the rational prescribing of ARVs and identified factors which contribute to poor prescribing skills and adherence to the National guidelines. A retrospective cross sectional approach was used in studying a sample of pregnant HIV women attending different health institutions in Bushenyi District as from 1st January 2008 to 31 st December 2...
Cancer is a group of diseases characterised by uncontrolled proliferation of cells. Of all the types of cancers worldwide, breast cancer is the most commonly diagnosed in women while prostate cancer is the second in men. The current cancer management methods have challenges including unpleasant side effects, high cost and even not effective. As the number of patients is on the rise, physicians look forward with hope to the discovery and development of safe, effective and less toxic anticancer...
ABSTRACT. Irrational prescribing of ARVs to HIV pregnant women is a major problem of poor control of HIV/AIDS all over the world. The researcher assessed the rational prescribing of ARVs and identified factors which contribute to poor prescribing skills and adherence to the National guidelines. A retrospective cross sectional approach was used in studying a sample of pregnant HIV women attending different health institutions in Bushenyi District as from 1st January 2008 to 31st December 2009....
ABSTRACT Background Despite the fact that herbal medicines are used by 80% of the World's population (WHO, 2002) and are the main source of health care in the rural communities and the most preferred form of treatment of HIV-related symptoms (Orisatoki and Oguntibeju, 2010), less than 10% of herbal products in the world market are truly standardized to a known active and/or toxic components (Winston et al., 2007). Study carried out in Western Uganda reported 32.8% of same-day use of herbal m...
Abstract A cross sectional study was conducted in Bushenyi district to review the side effects, adverse effects and the process of collecting herbal medicines between September 2013 and February 2014. The study found out that traditional herbs were being widely used in Bushenyi district in the treatment of malaria, cough, vaginal dryness, abdominal cramps, erectile dysfunction and fevers most frequently than other conditions. The study also found that the most common side effects were nausea ...
ABSTRACT Backgrmmd: More than 50% of all medicines are irrationally used in the world. Rational use of medicines (RUM) means that the right patient receives the right drug, in the right dose, for the right duration, and at the lowest cost for him/her and the community. In a nutshell treatment must follow the standard treatment guidelines of that area. In this case Uganda, the Uganda Clinical Guidelines for treatment of Common Infections is used. The problem of rational use is even most dire w...
Table of Contents DECLARATION ............................................................................................................................................ i ACKNOWLEDGEMENTS .......................................................................................................................... ii ABBREVIATIONS ...................................................................................................................................... vi CHAPTER ONE: INTRODUCTION ......