Virgin coconut oil (VCO) is a saturated fat with promising antidiabetic properties but its ameliorative effect on lipid profilesin diabetics is rarely reported. Therefore, in this study, a total of fifteen (15) male rats weighing 200–250 g were divided into 3experimental groups (𝑛 = 5).Group I (control) andGroup II (diabetic control group) were fed a normal rat chowwhile Group III(diabetic test group) was fed a 10% VCO diet for 3 weeks. Group II and Group III were made diabetic by intrap...
Untreated hyperglycaemia leads to kidney damage through oxidative stress of the kidney tissues with resultantcompromise of the antioxidant enzymes. According to research, Virgin Coconut Oil (VCO) has been reported tohave hypoglycaemic and anti-diabetic properties. Therefore, this study was designed to investigate theameliorative effects of VCO supplemented diet on blood glucose, renal tissues and antioxidant enzymes indiabetic rats. The study was carried out on fifteen male rats weighing 150 ...
Introduction: Virgin coconut oil (VCO), a saturated fat,has been reported to have anti-diabetic properties and thereis dearth of information on its potency to correct abnormalhaemostatic parameters associated with diabetic patients.Objectives: Therefore, this study was carried out toinvestigate effect of VCO consumption on abnormalhaemostatic parameters in diabetic rats.Materials & Methods: A total of fifteen (15) male ratsweighing 200–250g were divided into three (3) experimentalgroups: No...
The effect of prolonged consumption of virgin coconut oil (VCO) diet on anxiety was assessed in CD1 mice using the Open field (OF), Elevated plus maze (EPM) and Light/dark box (LD box) tests. Thirty male CD1 mice (28.4-32.5 g bw) divided into 3 groups (n=10 each) were given normal rodent chow (control), 5% (w/w) and 20% (w/w) VCO diet respectively and water ad libitum for 23 days. The OF test showed increased grooming (p< 0.05) in both 5% and 20% VCO groups versus control, and higher Freeze f...
Page|3CHAPTERONE1.1INTRODUCTION.Haemostasisisthatbodilymechanismthatpreventsexcessivebloodlossfromthebodyduringdamagetotissues.Thehaemostaticsystemrepresentsadelicatebalancebetweenpro-coagulantandanti-coagulantmechanismslinkedtoaprocessoffibrinolysis(Sandhyarani&Kumar2014).Therearefivemajorcomponentsinvolvedinthehaemostaticsystemandtheseincludes;platelets,coagulationfactors,coagulationinhibitors,fibrinolysisandbloodvessels(Guyton&Hall2006).Haemostasisisalifesavingprocessandso,thestudyofsubsta...
Anti-diabetic and Anti-oxidant potentials of Aqueous Extract of Eucalyptus Globulus in experimentally induced diabetic rats.
Abstract The effect of aqueous extract of Moringa oleifera seed on serum cortisol and body weights was investigated in 24 adult Wistar rats for 21 days. Dried Moringa oleifera seeds were powdered by an electric blender. With the aid of an oven regulated at 400C and water, the Moringa oleifera seed extract was produced. The extract was dissolved in 5% Tween 80 solution to produce aqueous extract with concentration of 200mg/ml. The rats with a mean body weight of 144±43.1g were divided into ...
Abstract Adiponectin first described in 1995 as a peptide of adipose tissue that becomes dysregulated in obesity. Adiponectin is an adipokine produced and secreted exclusively by both white adipose tissue (WAT) and brown adipose tissue. It accounts for about 0.01% of the total plasma protein in humans. It is the most abundant protein secreted by the adipose tissue.The role of adiponectin is mediated by receptors known as adiponectin receptors 1 and 2 (Adipor1 and Aipor2). These receptors ha...
Lingual lipase is a water soluble enzyme that primarily catalyses the breakdown of fats and converts them to free fatty acids, monoglycerides and diglycerides. They play an important role in food digestion. Lingual lipase which was discovered in 1976 is a member of a family of digestive enzymes called triacylglycerol lipases, that use the catalytic triad of aspartate, and serine to hydrolyze medium- and long-chain triglycerides into partial glycerides and free fatty acids.
ABSTRACT The Gastro intestinal system is vital for overall secretions, digestion, absorption, and movement within the tracts. Secretions involve release of fluids, chemicals and catalytic substances that facilitates digestion and related gastrointestinal tract (GIT) activities. Digestion involves hydrolysis of condensed products of carbohydrates, proteins and fats. Absorption involves movement of molecules across the GIT into the circulatory system. Carbohydrates are hydrolysed to monos...
ABSTRACT Orexins are recently discovered neuropeptides synthesized by neurons located in the posteriolateral hypothalamus. There are about 10,000 to 20,000 of these neurons in the hypothalamus and their axons extend throughout the brain and spinal cord where their receptors are located. The word Orexin is a Greek word reflecting orexigenic (appetite stimulating) activity of hormone. There are two types of Orexin – Orexin-A and Orexin-B – and these are essentially the same as hypocre...
Abstract The endocrine system is a system of glands, each of which secretes a type of hormone directly into the bloodstream to regulate the body. Many of the body's hormones influence growth, such as growth hormone, thyroxine, insulin, and corticosteroids (all of which influence growth rate), leptin (which alters body composition), and parathyroid hormone, 1,25-dihydroxy-vitamin D, and calcitonin (all of which affect skeletal mineralization). However, the key hormone in growth is GH which ...
Digestion is the breakdown of complex food substances into simple and absorbable form by the aid of enzymes using a process known as hydrolysis. Carbohydrate basically are divided into three: Polysaccharides (example Starch), Disaccharides (Sucrose and Lactose), and monosaccharides (Fructose, Galatose and Glucose). Almost all the carbohydrates of the diet are either large polysaccharides or disaccharides, which are combinations of monosaccharides bound to one another by condensation (Guyto...
Brown-Séquard syndrome, also known as Brown-Séquard's hemiplegia and Brown-Séquard's paralysis, is a loss of sensation and motor function (paralysis and anesthesia) that is caused by the lateral hemisection (cutting) of the spinal cord. This may be seen most often in the cervical (neck) or thoracic spine. Other synonyms are hemiparaplegic syndrome, hemiplegia ethemiparaplegiaspinalis, and spinal hemiparaplegia. Brown-Séquard syndrome is characterized by loss of motor function(i.e. hem...
Cell to cell signaling refers to the transfer of information from one cell to another. This is also called cell signaling or intercellular communication. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. The cells of the body communicate with each other...