The broad application of proteomics in different biological and medical fields, as well as the diffusion of high-throughput platforms, leads to increasing volumes of available proteomics data. Computational proteomics is the data science concerned with the identification and quantification of proteins from numerous data and the biological interpretation of their concentration changes, posttranslational modifications, interactions, and subcellular localizations. Computational proteomics is a h...
ABSTRACT Tea is one of the most popular non-alcoholic beverages worlwide, and a leading foreign exchange earner and source of livelihood to over three million people in Kenya. However, tea growing areas in Kenya experience abiotic stresses with drought been the most predominant. Tea plants tolerate drought through poorly understood physiological, cellular/biochemical and molecular processes. Development of tea cultivars adapted to water-deficit stress greatly relies on an understanding of me...
The highly developed and specialized anatomical and physiological characteristics observed for eukaryotes in general and mammals in particular are underwritten by an elaborate and intricate process of genome regulation. This precise control of the location, timing and amplitude of gene expression is achieved by a variety of genetic and epigenetic tools and mechanisms. Such tools include cis- and trans- transcriptional regulation, epigenetic marks and chromosomal conformation in the nucleus [7...
Ebola virus (EBOV) has recently emerged as a highly virulent organism of concern to humans. The pathology behind the hemorrhagic fever within an EBOV host remains largely unclear, and demands rather novel therapeutics to effectively eradicate this virus. The Niemann-pick type C1 (NPC1) protein cholesterol transporter is required for EBOV entry and internalization into a mammalian host cell. On this premise, an organism’s NPC1 can decide the virus-species specificity. Here, ...
We are pleased to see the three follow- up letters concerning our “World Scientists’ Warning to Humanity: A Second Notice” (Ripple et al. 2017). Each letter expresses a thoughtful, heartfelt response to our paper. We agree in how they describe the need to get more scientists into policymaking positions (Dror), to create a new global environmental ethic (Skubała), and to recognize economic growth as a major driver of environmental impacts (Pacheco et al.). The letters rais...
INTRODUCTION Just like water and air is important to the living human being for daily duties and a hitch – free survival, the importance of fuel to automobile cannot be over looked. A typical situation is in the cases halts because of the fact that there is shortage of fuel. The importance of fuels in this our developing and technically inclined economy is fast like the mixture of oil and salt as far as the economy forgets growth as one of its goals. Fuel is used in a variety of...
AbstractWheat grain quality are strongly influenced by the effects of environment during grain fill. Environmental variables such as temperature, water and fertilizer influence the rate and duration of wheat grain development, protein accumulation and starch deposition in unique ways, and by different mechanisms. The effects of environment are superimposed on the intrinsic temporal patterns of gene expression during grain development. Integration of genomic and proteomic studies with developm...