Abstract: The inhibitory effects of Momordica charantia linn, Isoberlinia doka, Terminalia avicennioides, Tamarindus indica and Crotalaria retusa L aqueous leaves extracts on Opisthacanthus capensis (Black creeping scorpion) venom phospholipase A2 (PLA2 ) activity was investigated. The enzyme from O. capensis venom had a pH and temperature optima of 5 and 60˚C respectively with an activation energy of 5.20 Kcal/mol. Different concentrations (4mg, 6mg and 8mg/ml) of Isoberlinia doka and Momordica charantia Linn inhibited the activity of O capensis venom PLA2 in vitro displaying an uncompetitive inhibition pattern with a decrease in the computed index of efficiency (Kcat). Different concentrations (4mg, 6mg and 8mg/ml) of Terminalia avicennioides, Tamarindus indica and Crotalaria retusa L also inhibited O. capensis venom PLA2 activity in vitro but the inhibition pattern was competitive inhibition with Kcat remaining unchanged. This study reveals that the use of these plants by herbalists in northern Nigeria in the treatment of scorpion bites could be justifiable.
Keywords: Opisthacanthus Capensis, Venom, Phospholipase A2, Scorpion, Envenomation
Maidala, A., Zanna, H , Ahmad, S , Abdulmalik, B , Tasi’u, M , Abel, G & Musa., H (2018). Herbal treatment of scorpion envenomation: Plant extracts inhibited Opisthacanthus capensis venom phospholipase A2 activity. Afribary. Retrieved from https://tracking.afribary.com/works/herbal-treatment-of-scorpion-envenomation-plant-extracts-inhibited-opisthacanthus-capensis-venom-phospholipase-a2-activity
Maidala, Ahmad, et. al. "Herbal treatment of scorpion envenomation: Plant extracts inhibited Opisthacanthus capensis venom phospholipase A2 activity" Afribary. Afribary, 19 Dec. 2018, https://tracking.afribary.com/works/herbal-treatment-of-scorpion-envenomation-plant-extracts-inhibited-opisthacanthus-capensis-venom-phospholipase-a2-activity. Accessed 12 Nov. 2024.
Maidala, Ahmad, Hassan Zanna , Sa’idu Ahmad , Babagana Abdulmalik , Magaji Tasi’u , Grace Abel and Hauwa Musa. . "Herbal treatment of scorpion envenomation: Plant extracts inhibited Opisthacanthus capensis venom phospholipase A2 activity". Afribary, Afribary, 19 Dec. 2018. Web. 12 Nov. 2024. < https://tracking.afribary.com/works/herbal-treatment-of-scorpion-envenomation-plant-extracts-inhibited-opisthacanthus-capensis-venom-phospholipase-a2-activity >.
Maidala, Ahmad, Hassan Zanna , Sa’idu Ahmad , Babagana Abdulmalik , Magaji Tasi’u , Grace Abel and Hauwa Musa. . "Herbal treatment of scorpion envenomation: Plant extracts inhibited Opisthacanthus capensis venom phospholipase A2 activity" Afribary (2018). Accessed November 12, 2024. https://tracking.afribary.com/works/herbal-treatment-of-scorpion-envenomation-plant-extracts-inhibited-opisthacanthus-capensis-venom-phospholipase-a2-activity