Abstract
In Nigeria the Federal Government rolled out antiretroviral drugs for the management of HW infection in year 2002. This study was carried out to determine the circulating antiviral drug mutations amrmg ARV naive patients with chronic HIV infection durillg the pre-ARV roll out era in &e country. DNA was extracted from scored whole blood samples collected from 75 HlV positive patients attending the Medical outpatient clinic between December 19% and November 2001. The Reverse mscriptase 0 and the protease (PR) regions of the viral genome were amplified by nested PCR and then sequenced by cycle sequencing and analyzed using the ABI 3100 DNA sequencer to determine the mutations assdated with protease inhibitors (PI), nudeoside reverse transcriptase inhibitors @RTlJ and non-nucIeoside reverse transcriptase inhibitor (NNRTz). Ten of the 64 (1 5.6%) samples with positive PCR bad mutations for PR inhibitors (PI) including R8D. I 15V, G16E, MW, M46L, L63P and H69K, while 5 of63 harbored RT inhibitor (NRTUNNRTI); V179I, MBT, V179E and A98S. Detection ofARV drug resistant mutations when ARV was not known to be in use in Nigeria caIls for caution in the intedpretatim of drug resistance prome of HIV-1 from infected pons on treatment ARVs in the counq
Network, P. (2021). HW-1 Drug Resistant Mutations In Chronically Infected -Treatment Naive Individuals in The Pre-ARV Era in Nigeria. Afribary. Retrieved from https://tracking.afribary.com/works/hw-1-drug-resistant-mutations-in-chronically-infected-treatment-naive-individuals-in-the-pre-arv-era-in-nigeria
Network, Pub "HW-1 Drug Resistant Mutations In Chronically Infected -Treatment Naive Individuals in The Pre-ARV Era in Nigeria" Afribary. Afribary, 16 May. 2021, https://tracking.afribary.com/works/hw-1-drug-resistant-mutations-in-chronically-infected-treatment-naive-individuals-in-the-pre-arv-era-in-nigeria. Accessed 18 Dec. 2024.
Network, Pub . "HW-1 Drug Resistant Mutations In Chronically Infected -Treatment Naive Individuals in The Pre-ARV Era in Nigeria". Afribary, Afribary, 16 May. 2021. Web. 18 Dec. 2024. < https://tracking.afribary.com/works/hw-1-drug-resistant-mutations-in-chronically-infected-treatment-naive-individuals-in-the-pre-arv-era-in-nigeria >.
Network, Pub . "HW-1 Drug Resistant Mutations In Chronically Infected -Treatment Naive Individuals in The Pre-ARV Era in Nigeria" Afribary (2021). Accessed December 18, 2024. https://tracking.afribary.com/works/hw-1-drug-resistant-mutations-in-chronically-infected-treatment-naive-individuals-in-the-pre-arv-era-in-nigeria