Abstract
Current standard of care treatment modalities for early-stage breast cancer typically involve mastectomy or lumpectomy followed by radiation therapy to remove any residual cancer cells. Although mastectomy has a low recurrence rate, it is an aggressive form of treatment for early-stage breast cancer. Therefore, there is a need for the development of new strategies that could increase the use of lumpectomy by eliminating residual cancer cells to reduce local recurrence with limited side effects. Our research group has previously reported in-vitro hyperthermia via Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane (PDMS) as a potential treatment method that can kill residual cancer cells. In order to move to in-vivo applications, we developed a model for the estimation of the damage zones created by the device in biological media and also explored new heating mechanisms. First, we developed a three-dimensional coupled finite element method (FEM) model that enables the prediction of thermal damage. The model was validated with experimental results. Secondly, we explored the use of magnetic nanoparticle (MNP) heating as an alternative to Joule heating that was used in the previous studies. MNP-reinforced PDMS composites (nanocomposites) were fabricated and characterized to determine their structural, magnetic and thermal properties.
Kan-Dapaah, K (2021). Implantable Composite Devices for the Localized Treatment of Breast Cancer. Afribary. Retrieved from https://tracking.afribary.com/works/implantable-composite-devices-for-the-localized-treatment-of-breast-cancer
Kan-Dapaah, Kwabena "Implantable Composite Devices for the Localized Treatment of Breast Cancer" Afribary. Afribary, 13 Apr. 2021, https://tracking.afribary.com/works/implantable-composite-devices-for-the-localized-treatment-of-breast-cancer. Accessed 22 Dec. 2024.
Kan-Dapaah, Kwabena . "Implantable Composite Devices for the Localized Treatment of Breast Cancer". Afribary, Afribary, 13 Apr. 2021. Web. 22 Dec. 2024. < https://tracking.afribary.com/works/implantable-composite-devices-for-the-localized-treatment-of-breast-cancer >.
Kan-Dapaah, Kwabena . "Implantable Composite Devices for the Localized Treatment of Breast Cancer" Afribary (2021). Accessed December 22, 2024. https://tracking.afribary.com/works/implantable-composite-devices-for-the-localized-treatment-of-breast-cancer