ABSTRACT
Background Beneficial effects of Intermittent Preventive Treatment in pregnancy (IPTP-SP) on the mother and birth outcomes are known. The few studies on the effects of IPTp-SP beyond in utero have been contradictory and tended to focus on late infancy and beyond. Mechanisms and targets explaining effects of IPTp-SP beyond in utero remain largely unknown. This study determined if IPTp-SP use was associated with risk of malaria and all cause mortality in early infancy and if maternally transferred antibody levels (Total IgG) to malarial antigens could explain observed IPTp-SP effects or were independently associated with the aforementioned outcomes. Methods This study was undertaken by conducting secondary analyses of the whole data from a five year cohort of 2279 newborns enrolled between 2006 and 2007 in the Kassena-Nankana Districts. Analysis was restricted to early infancy. Survival techniques (Cox Proportional hazards and Kaplan-Meier plots) were used to estimate frequency of IPT-SP doses and risk of malaria and all cause mortality. ELISA assays performed on a subset of the cohort (672), measured total IgG antibody titres to selected malaria antigens and frequency of IPTp-SP doses. Analyses of variance (ANOVA), simple regression techniques and box plots were employed to determine associations between antibody titres and frequency of IPTp-SP doses. IPTp-SP dosing frequency, Antibody types and risk of malaria and all cause mortality were also measured. Statistical significance was set at 5% with 95% confidence interval. Results Infants of mothers who had one dose of IPTp-SP had 44% less risk of parasitaemia [Hazards Ratio (HR) =0.60(95%CI= 0.45, 0.79), P
ACHEMBONA, A (2021). MALARIA IN EARLY INFANCY: EFFECT OF INTERMITTENT PREVENTIVE TREATMENT OF MALARIA IN PREGNANCY (IPTp) AND MATERNALLY TRANSFERRED ANTIBODIES IN THE KASSENA-NANKANA DISTRICT.. Afribary. Retrieved from https://tracking.afribary.com/works/malaria-in-early-infancy-effect-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-iptp-and-maternally-transferred-antibodies-in-the-kassena-nankana-district
ACHEMBONA, ATUGUBA "MALARIA IN EARLY INFANCY: EFFECT OF INTERMITTENT PREVENTIVE TREATMENT OF MALARIA IN PREGNANCY (IPTp) AND MATERNALLY TRANSFERRED ANTIBODIES IN THE KASSENA-NANKANA DISTRICT." Afribary. Afribary, 25 Mar. 2021, https://tracking.afribary.com/works/malaria-in-early-infancy-effect-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-iptp-and-maternally-transferred-antibodies-in-the-kassena-nankana-district. Accessed 21 Sep. 2024.
ACHEMBONA, ATUGUBA . "MALARIA IN EARLY INFANCY: EFFECT OF INTERMITTENT PREVENTIVE TREATMENT OF MALARIA IN PREGNANCY (IPTp) AND MATERNALLY TRANSFERRED ANTIBODIES IN THE KASSENA-NANKANA DISTRICT.". Afribary, Afribary, 25 Mar. 2021. Web. 21 Sep. 2024. < https://tracking.afribary.com/works/malaria-in-early-infancy-effect-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-iptp-and-maternally-transferred-antibodies-in-the-kassena-nankana-district >.
ACHEMBONA, ATUGUBA . "MALARIA IN EARLY INFANCY: EFFECT OF INTERMITTENT PREVENTIVE TREATMENT OF MALARIA IN PREGNANCY (IPTp) AND MATERNALLY TRANSFERRED ANTIBODIES IN THE KASSENA-NANKANA DISTRICT." Afribary (2021). Accessed September 21, 2024. https://tracking.afribary.com/works/malaria-in-early-infancy-effect-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-iptp-and-maternally-transferred-antibodies-in-the-kassena-nankana-district