MECHANISM OF DIAPEDESIS

44 PAGES (15526 WORDS) Physiology Seminar

Diapedesis is the means by which cells cross the walls of intact vessels. For those interested in assessing new methods for cancer therapy, I believe there are great strides to be accomplished if more efforts are concentrated on this phenomenon.

CHAPTER ONE: INTRODUCTION 9

CHAPTER   TWO:  ADVANCEMENTS   IN   DIAPEDESIS,   THE   PRECEEDING   STEPSAND HOW THEY ARE REGULATED 112.0.1 ADVANCEMENTS IN DIAPEDESIS 112.0.2 CLONING 122.0.2.1 CLONING AND DIAPEDESIS 122.1 SITES WHERE DIAPEDESIS OCCUR 132.2 TUMOUR CELL DIAPEDESIS2.3 LEUKOCYTE AND ENDOTHELIUM INTERACTION 152.4 STEPS INVOLVED IN DIAPEDESIS 19

CHAPTER THREE: DIAPEDESIS 24 3.1 MECHANISM OF DIAPEDESIS 273.2 CONTROL/REGULATION OF DIAPEDESIS 29CHAPTER FOUR: WHAT   IS   RESPONSIBLE   FOR   THE   DIFFERENCES   INMIGRATION ROUTES?  414.1 ESAM 414.2 PECAM-1 41v

4.3   ACTIVATION   STATE   OF   THE   ENDOTHELIAL   CELLS   AND   ICAM-1EXPRESSION LEVEL 414.4 NATURE OF THE INFLAMMATORY STIMULUS 424.5 NATURE OF THE ENDOTHELIUM 424.6 INTEGRINS  43

CHAPTER FIVE: CONCLUSION 44ABBREVIATIONS  45REFERENCES 46