ABSTRACT Background: The use of Xylopia aethiopica fruit in folklore medicine is on the increase without regard to its toxicity. Aim: This study was aimed at examining its toxicity on the kidney of Wistar rats. Methodology: The fruits of Xylopia aethiopica were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard method. Thirty Wistar rats were divided into five groups of six rats each. Animals in groups A, B, C, and D were administered 129.62, 259.23, 388.85 and 518.46 mg/kg body weight of X. aethiopica fruit extract respectively, while those in group E received normal feeds and water only. The administration was done once daily for 28 days via oral route. Renal indices were determined using standard methods. Results: Elevation in creatinine and urea levels was observed when experimental animals were compared with those in control group. This elevation was insignificant at a low dose of 129.62 mg/kg but significant (P
Airaodion, A. (2021). Nephrotoxicity of Ethanol Extract of Xylopia aethiopica. Afribary. Retrieved from https://tracking.afribary.com/works/nephrotoxicity-of-ethanol-extract-of-xylopia-aethiopica
Airaodion, Augustine "Nephrotoxicity of Ethanol Extract of Xylopia aethiopica" Afribary. Afribary, 13 Jan. 2021, https://tracking.afribary.com/works/nephrotoxicity-of-ethanol-extract-of-xylopia-aethiopica. Accessed 23 Nov. 2024.
Airaodion, Augustine . "Nephrotoxicity of Ethanol Extract of Xylopia aethiopica". Afribary, Afribary, 13 Jan. 2021. Web. 23 Nov. 2024. < https://tracking.afribary.com/works/nephrotoxicity-of-ethanol-extract-of-xylopia-aethiopica >.
Airaodion, Augustine . "Nephrotoxicity of Ethanol Extract of Xylopia aethiopica" Afribary (2021). Accessed November 23, 2024. https://tracking.afribary.com/works/nephrotoxicity-of-ethanol-extract-of-xylopia-aethiopica