Occurrence Of Rectal Gonorrhoea And Chlamydia And Antibiotic Susceptibility Profile Among Men Who Have Sex With Men At The Kenyan Coast

ABSTRACT

Men who have sex with men experience a high burden of Chlamydia trachomatis and Neisseria gonorrhoea infections which remain largely undiagnosed in the context of syndromic and presumptive treatment. In Kenya, limited data is available to inform on occurrence and recurrence of rectal chlamydia and gonorrhoea and antibiotic sensitivity on Neisseria gonorrhoea among Men who have sex with men who report receptive anal intercourse. The aim of this study was to determine the occurrence, recurrence and reinfection of rectal Neisseria gonorrhoea and Chlamydia trachomatis infections among Men who have sex at the Kenyan Coast. This study also compared the performance of Gram stain and Gene Xpert in the detection of chlamydia and gonorrhoea and determined the antibiotic sensitivity profile of N. gonorrhoea. The study was carried out in Kemri-Wellcome Trust Program Mtwapa Research clinic employing a longitudinal cohort study design and purposeful sampling technique. Men who had sex with men enrolled in ongoing larger cohort studies and who reported receptive anal intercourse in the past six months were involved in this study. Three rectal swabs were collected and analysed by Gram stain, culture on Thayer Martin medium and molecular point of care technique by use of the Gene Xpert analyser. All gonorrhoea isolates were subjected to antibiotic sensitivity test. Results in this study were analysed using Stata version 13.0 (Stata Corp LP, college station, United States of America) and significance level set at P