PREVALENCE OF WOUND SEPSIS AND ASSOCIATED FACTORS AMONG POST-OPERATIVE PATIENTS IN KAMPALA INTERNATIONAL UNIVERSITY TEACHING HOSPITAL, ISHAKA, BUSHENYI-WESTERN UGANDA

Table of Contents DECLARATION........................................................................................................................... ii APPROVAL .................................................................................................................................iii Table of Contents......................................................................................................................... vi LIST OF ACRONYMS .............................................................................................................. vii ABSTRACT................................................................................................................................ viii CHAPTER THREE.................................................................................................................... 13 METHODOLOGY ..................................................................................................................... 13 3.2.0. Study Area ......................................................................................................................... 13 3.4.0. Sample size determination ............................................................................................... 13 3.5.0. Study Population............................................................................................................... 14 3.5.1. Inclusion criteria............................................................................................................. 14 3.5.2. Exclusion criteria............................................................................................................ 14 3.6.0. Sampling method .............................................................................................................. 14 3.8.0 Study variables................................................................................................................... 14 3.8.1 Dependent variable ............................................................................................................ 14 3.8.2 Independent variables ....................................................................................................... 15 3.9.0 Data collection .................................................................................................................... 15 3.12.0 Quality control ................................................................................................................. 15 3.14.0. Ethical consideration ...................................................................................................... 16 CHAPTER FOUR....................................................................................................................... 17 RESULTS .................................................................................................................................... 17 CHAPTER FIVE:....................................................................................................................... 26 DISCUSSION.............................................................................................................................. 26 STRENGTH AND WEAKNESSES;......................................................................................... 28 5.5 CONCLUSIONS ................................................................................................................... 28 5.6 RECOMMENDATIONS...................................................................................................... 28 REFERENCES: .......................................................................................................................... 29 APPENDIX 1: CONSENT FORM............................................................................................ 31 APPENDIX 2: QUESTIONNAIRE........................................................................................... 32 APPENDIX 3. CHECKLIST..................................................................................................... 34 APPENDIX 4: RESEARCH WORK PLAN ............................................................................ 36 APPENDIX 7: MAP OF LOCATION OF ISHAKA BUSHENYI MUNICIPALITY ......... 38 vii LIST OF ACRONYMS AMP Antimicrobial prophylaxis BMI Body mass index C-SECTION Caesarean section GOPD General Out Patient Department. ICU Intensive Care Unit KIUTH Kampala International University Teaching Hospital MBRRH Mbarara Regional Referral Hospital MOH Ministry Of Health NHSN National Health Science Association. SAHS School of Allied Health Sciences SSI Surgical Site Infection. UNICEF United Nations International Children‟s E mergence Fund WHO World Health Organization viii ABSTRACT Background of the study; Post-operative wound sepsis is among the commonest complications of surgery, especially in developing countries. This complication often increases the burden on patients; increases hospitalization duration, painful wound dressings and other procedures like debridement and secondary closure, drugs burden, and the associated increased hospital bills. Objective; To obtain the prevalence, and factors associated with wound sepsis among postoperative patients in KIUTH. Methods: A cross-sectional study design that is both descriptive and analytical was used. The study was carried out between August and December 2017 in Kampala international university teaching hospital, where participants were chosen according to our inclusion and exclusion criteria. Results; The prevalence of post-operative wound sepsis in KIUTH was found at 25.3%, with a higher prevalence in Emergency compared to Elective surgeries (cOR 2.552, P=0.016, 95% CI, 1.194-5.456) Post-operative wound sepsis was found to be significantly associated with ineffective use of antimicrobial prophylaxis pre-operatively (aOR 0.176, P=0.010 95% CI 0.120-0.751). There was also noted a high association between post-operative wound sepsis and long Midline incisions, (cOR 2.308, P=0.116 95% CI 0.812-6.555), although this factor wasn‟t statistically significant. The condition was however not found to be associated with Age and Patients underlying illness in this study, as it had been reported in many previous studies. Conclusion: The study found a high prevalence of wound sepsis among post-operative patients, which was dependent ineffective use of Antimicrobial prophylaxis pre-operatively, and the use long midline incisions during surgery