ABSTRACT
Serum electrolytes disorders in HIV patients in addition to resulting from disease induced
fluids losses or accumulation could be attributed to a wide range of structural defects of
cellular apparatus, tissue or organs of regulation. Most routine clinical investigation of
impaired serum electrolytes in HIV infection limit attribution to body fluids charges and to
primary organs of regulations. Such investigations do not address the likelihood of
existence of multiple regulatory organs defects, the contribution of secondary regulatory
organs and of non elemental electro chemical forces in establishing observed serum
electrolytes states in HIV infection. This study investigated the association of electrolytes
levels with kidney and liver functions in HIV infection in order to explore the extent of
contribution of the renal and gastrointestinal primary regulatory organs to existing serum
electrolytes disorders in light of the extended range of HIV impact on multiple organs of
electrolytes regulation. This was a hospital based cross sectional study enrolling
consecutive attendants of the PSC at Jaramogi Oginga Odinga Teaching and Referral
Hospital. 800 HIV-infected and 406 seronegative controls were enrolled. Biochemical
analysis was done of serum levels of major electrolytes (Na+, K+ and Cl-), markers of
kidney function (creatinine and urea) and liver pathology (bilirubin, albumin, total protein
and enzymes) and related body fluids parameters (osmolality and pressure). Frequency
counts and measures of central tendency and dispersion around normal reference values
were used to assess the distribution of analytes in the population. Associations of HIV
status, CD4 count, ARV use, age and gender with electrolytes and fluid parameters were
tested using, t-tests and Chi-square and regression logistics (r and r2) and significance
levels assigned using α = 0.05. Female gender, increasing age and CD4
OUMA, O (2021). Serum Electrolyte Changes Associated With Kidney And Liver Function Markers In Hiv-Infected Individuals Attending Jaramogi Oginga Odinga Teaching And Referral Hospital, Kisumu County, Kenya. Afribary. Retrieved from https://tracking.afribary.com/works/serum-electrolyte-changes-associated-with-kidney-and-liver-function-markers-in-hiv-infected-individuals-attending-jaramogi-oginga-odinga-teaching-and-referral-hospital-kisumu-county-kenya
OUMA, OPIYO "Serum Electrolyte Changes Associated With Kidney And Liver Function Markers In Hiv-Infected Individuals Attending Jaramogi Oginga Odinga Teaching And Referral Hospital, Kisumu County, Kenya" Afribary. Afribary, 07 May. 2021, https://tracking.afribary.com/works/serum-electrolyte-changes-associated-with-kidney-and-liver-function-markers-in-hiv-infected-individuals-attending-jaramogi-oginga-odinga-teaching-and-referral-hospital-kisumu-county-kenya. Accessed 24 Nov. 2024.
OUMA, OPIYO . "Serum Electrolyte Changes Associated With Kidney And Liver Function Markers In Hiv-Infected Individuals Attending Jaramogi Oginga Odinga Teaching And Referral Hospital, Kisumu County, Kenya". Afribary, Afribary, 07 May. 2021. Web. 24 Nov. 2024. < https://tracking.afribary.com/works/serum-electrolyte-changes-associated-with-kidney-and-liver-function-markers-in-hiv-infected-individuals-attending-jaramogi-oginga-odinga-teaching-and-referral-hospital-kisumu-county-kenya >.
OUMA, OPIYO . "Serum Electrolyte Changes Associated With Kidney And Liver Function Markers In Hiv-Infected Individuals Attending Jaramogi Oginga Odinga Teaching And Referral Hospital, Kisumu County, Kenya" Afribary (2021). Accessed November 24, 2024. https://tracking.afribary.com/works/serum-electrolyte-changes-associated-with-kidney-and-liver-function-markers-in-hiv-infected-individuals-attending-jaramogi-oginga-odinga-teaching-and-referral-hospital-kisumu-county-kenya