ABSTRACT
A number of essential trace elements play major roles in various metabolic pathways.
Deficiencies or alterations in the level of these trace elements adversely affect the ability to
withstand oxidative stress-mediated cell damage. This study determined the serum status of
copper, zinc and manganese in psychiatric patients. One hundred (100) psychiatric patients
attending the Neuropsychiatric Hospital Enugu, Nigeria were categorized into two groups:
fifty (50) patients on antipsychotic drugs and fifty (50) psychotic drug naive patients seen at
the emergency unit of the hospital. Fifty (50) apparently healthy subjects matched for age and
sex served as control. The concentration of zinc (Zn), copper (Cu) and manganese (Mn) were
determined using atomic absorption spectrophotometer (AAS). The mean serum levels of
zinc, copper and manganese in psychotics on drug were 86.75±5.39ug/dl, 95.77±7.71ug/dl
and 5.72±2.58ug/dl. In drug naïve patients the mean serum trace element levels were zinc
59.20±18.44ug/dl, copper 121.70±20.90ug/dl and manganese 9.30±7.51ug/dl. The mean
serum levels of these trace elements in the control subjects were zinc 86.95±5.64ug/dl,
copper 96.41±8.10ug/dl and manganese 5.78±2.57ug/dl. In psychotics on drug the serum
zinc, copper and manganese concentration levels remained unchanged compared with the
control (p>0.05). The drug naïve patients showed significantly lower serum zinc level
(p
VIVIAN, M (2021). Serum Trace Element Status Of Psychiatric Patients At Federal Neuropsychiatric Hospital Enugu Nigeria. Afribary. Retrieved from https://tracking.afribary.com/works/serum-trace-element-status-of-psychiatric-patients-at-federal-neuropsychiatric-hospital-enugu-nigeria
VIVIAN, MUOGHALU "Serum Trace Element Status Of Psychiatric Patients At Federal Neuropsychiatric Hospital Enugu Nigeria" Afribary. Afribary, 13 May. 2021, https://tracking.afribary.com/works/serum-trace-element-status-of-psychiatric-patients-at-federal-neuropsychiatric-hospital-enugu-nigeria. Accessed 21 Nov. 2024.
VIVIAN, MUOGHALU . "Serum Trace Element Status Of Psychiatric Patients At Federal Neuropsychiatric Hospital Enugu Nigeria". Afribary, Afribary, 13 May. 2021. Web. 21 Nov. 2024. < https://tracking.afribary.com/works/serum-trace-element-status-of-psychiatric-patients-at-federal-neuropsychiatric-hospital-enugu-nigeria >.
VIVIAN, MUOGHALU . "Serum Trace Element Status Of Psychiatric Patients At Federal Neuropsychiatric Hospital Enugu Nigeria" Afribary (2021). Accessed November 21, 2024. https://tracking.afribary.com/works/serum-trace-element-status-of-psychiatric-patients-at-federal-neuropsychiatric-hospital-enugu-nigeria