ABSTRACT
The immunoglobulin G (IgG) receptors FcyRIIa and FcyRIIIb vary among different
ethnic groups, and more importantly, are also known to be associated with either
susceptibility to or protection from certain diseases. These variations are manifest as
differences in the antigen-binding capabilities of the receptors. The genes encoding
for these receptors are polymorphic and these also vary among populations. These
variations can be investigated using molecular methods such as PCR. The aim of the
present study was to determine if there were any significant differences in the
distribution of these genotypes among some of the ethnic groups in Ghana and also if
there was any association between the genotypes and the incidence of severe malaria.
A total number of 329 children, belonging to four different tribes were recruited for
the study, of which 75 healthy individuals formed the control group. The 254
patients who were recruited were diagnosed as having uncomplicated, severe
anaemia or cerebral malaria. Human DNA was isolated from filter paper blood blots
for PCR analysis using allele-specific primers for FcyRIIa to detect H/H131,
H/R131, R/R131, and FcyRIIIb to detect NA1/NA1 and NA2/NA2 genotypes.
The results obtained revealed that there was no association between ethnicity and the
FcyRIIa genotype, (P=0.78) and FcyRIIIb genotypes (P=0.23). W ith regard to the
incidence of malaria and the FcyRIIa genotypes, the following associations were
found (P0.05.
The homozygous NA1/NA1 was found to be significantly dominant among the
patient group (P=0.003). The NA2/NA2 genotype on the other hand was
significantly reduced in the patient group (P=0.000), and also in all the three forms of
the diseases (P< 0.04). The heterozygous NA1/NA2 was found to be intermediate
between the two, but was significantly underepresented in the cerebral and severe
anaemia patients (P< 0.001). The null genotype was found to be overepresented
within the patient group (P=0.02).
These findings suggest that the NA2 offers protection against all forms of malaria
and this effect is even observed in the heterozygotes NA1/NA2 among the severe
anaemia and cerebral malaria groups. NA1, on the other hand is a heritable
predisposing factor to symptomatic malaria.
OGOE, B (2021). Studies On The Distribution Of The Allotypic Variants Of The Igg Receptors (Fcyriia And Fcyrihb) And Their Association With Severe Clinical Malaria Among Ghanaian Children. Afribary. Retrieved from https://tracking.afribary.com/works/studies-on-the-distribution-of-the-allotypic-variants-of-the-igg-receptors-fcyriia-and-fcyrihb-and-their-association-with-severe-clinical-malaria-among-ghanaian-children
OGOE, BRIDGETTE-MARIAN "Studies On The Distribution Of The Allotypic Variants Of The Igg Receptors (Fcyriia And Fcyrihb) And Their Association With Severe Clinical Malaria Among Ghanaian Children" Afribary. Afribary, 15 Apr. 2021, https://tracking.afribary.com/works/studies-on-the-distribution-of-the-allotypic-variants-of-the-igg-receptors-fcyriia-and-fcyrihb-and-their-association-with-severe-clinical-malaria-among-ghanaian-children. Accessed 22 Nov. 2024.
OGOE, BRIDGETTE-MARIAN . "Studies On The Distribution Of The Allotypic Variants Of The Igg Receptors (Fcyriia And Fcyrihb) And Their Association With Severe Clinical Malaria Among Ghanaian Children". Afribary, Afribary, 15 Apr. 2021. Web. 22 Nov. 2024. < https://tracking.afribary.com/works/studies-on-the-distribution-of-the-allotypic-variants-of-the-igg-receptors-fcyriia-and-fcyrihb-and-their-association-with-severe-clinical-malaria-among-ghanaian-children >.
OGOE, BRIDGETTE-MARIAN . "Studies On The Distribution Of The Allotypic Variants Of The Igg Receptors (Fcyriia And Fcyrihb) And Their Association With Severe Clinical Malaria Among Ghanaian Children" Afribary (2021). Accessed November 22, 2024. https://tracking.afribary.com/works/studies-on-the-distribution-of-the-allotypic-variants-of-the-igg-receptors-fcyriia-and-fcyrihb-and-their-association-with-severe-clinical-malaria-among-ghanaian-children