Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol

ABSTRACT

The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic drugs, From the literature, non-steroidal anti-inflammatory agents have covered a wide range of chemical structures aryl acetic, aryl-propionic, arylbutyric and anthranilic ' acid derivatives, Other compounds including the benzothiazines are also known to be potent agents. This work involved the synthesis of some amino methyl derivatives of 2-naphthol and screening them as potential anti-inflammatory agents. These derivatives from the point of view of their electronic and stereochemical characteristics are considered to be similar to the known bis(2-hydroxynaphthy1)- methane derivatives, earlier L'G+UL led iu ilave pronounced anti-inflammatory activity, The physicochemical properties of these compounds were .also determined in an effort to correlate observed biological activity and chemical structure.

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APA

Consults, E. & John, M (2023). Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol. Afribary. Retrieved from https://tracking.afribary.com/works/synthesis-and-anti-inflammatory-properties-of-aminomethyl-derivatives-of-2-naphthol

MLA 8th

Consults, Education, and MBAH John "Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol" Afribary. Afribary, 27 Apr. 2023, https://tracking.afribary.com/works/synthesis-and-anti-inflammatory-properties-of-aminomethyl-derivatives-of-2-naphthol. Accessed 06 Nov. 2024.

MLA7

Consults, Education, and MBAH John . "Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol". Afribary, Afribary, 27 Apr. 2023. Web. 06 Nov. 2024. < https://tracking.afribary.com/works/synthesis-and-anti-inflammatory-properties-of-aminomethyl-derivatives-of-2-naphthol >.

Chicago

Consults, Education and John, MBAH . "Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol" Afribary (2023). Accessed November 06, 2024. https://tracking.afribary.com/works/synthesis-and-anti-inflammatory-properties-of-aminomethyl-derivatives-of-2-naphthol

Document Details
By: Education Consults MBAH Chika John Field: Pharmacology Type: Project 197 PAGES (69474 WORDS) (pdf)