ABSTRACT The ethanolic leaves extracts of Hymenocardia acida was screened for anti-diabetic activity based on folklore and little or no work cited in literature. Hymenocardia acida (Family: Hymenocardiaceae) has a very high anti-diabetic potentials which appeared comparable to the control glibenclamide in alloxan induced diabetes mellitus. The study evaluated the ethanolic leaves extract of H. acida for anti-diabetic activity in a rat model of non-insulin dependent diabetes mellitus (NIDDM)....