Human African trypanosomiasis, which is commonly known as sleeping sickness, is a parasitic vector borne disease. The parasites involved are protozoans belonging to the genus Trypanosoma. To assess the acute toxicity and in vitro antitrypanosomal activity of tacazzea apiculata methanol root extract. Five hundred gram (500g) of the stored sample (roots) of T. apiculata was weigh on a weighing balance and the sample was transferred into a conical flask and macerated in 500ml of 95% methanol. Th...