Background: The use and abuse of psychoactive substances among adolescents pose serious health problems in society. It is crucial to ascertain the factors predisposing adolescents to this in order to enable action by stakeholders. This study was conducted to determine the prevalence and factors associated with psychoactive substance use among in-school adolescents in Zaria Local Government Area (LGA) of Kaduna State, Nigeria. Methods: A descriptive cross-sectional study was conducted in nine ...