Abstract Most stains used in histopathology are synthetic, toxic and costly for use. Hence, this study was carried out at the Histopathology Laboratory of Imo State University to find out the probability of replacing routine toxic and costly stains for nature, non-toxic, less costly and effective stains. Sixteen (16) kidney tissue sections were used for this study obtained from the Federal Medical Center, Owerri of which was divided into two groups of eight (8) kidney sections respectively. T...