Activation of caspase 3&9 by methanol extract of Gloriosa superba ABSTRACT Mitochondrion is the key regulator in cellular energy homeostasis and plays a central role in determining cell apoptotic process; it is therefore regarded as a vital target for cancer chemotherapy. Cancer is obviously one of the most common areas where demand for alternative treatment is overwhelming. Many investigations revealed that bioactive compounds in natural products can act on mitochondria to trigger the per...
Methanol extract of Gloriosa superba in this research was adopted due to the presence of photochemicals present in the plant. This photochemicals are known to act as antioxidants and anti tumor agent but it is not yet known if the activity of the plant is through the mitochondria mediated pathway, caspase activation and induction of apoptosis where up regulation is necessary
