ABSTRACT Ivermectin (IVM), a dihydro derivative of avermectin (AVM), originating solely from the fermentation products of Streptomyces avermitilis had an immeasurably beneficial impact in improving the lives and welfare of billions of people worldwide. Originally introduced as a veterinary drug, it was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases; onchocerciasis and lymphatic filariasis (LF) which has plagued the world’s poor ...
ABSTRACT Tungiasis is an ecto-parasitic disease of humans and animals caused by the burrowing of gravid female fleas of the genus ‘Tunga’. Of the known species of Tunga fleas, Tunga penetrans and Tunga trimamillata are parasites of humans besides other warm blooded mammals, most of which are peri-domestic. The host of the others is limited to a few genera of wild mammals. The burrowed female flea rapidly expands its body size, causing immense itching, inflammation, pain and debilitation. ...
Reasons for reviewing the article • Addresses a NTD that is of public health importance. • Focuses on factors associated with high prevalence and intensity of the disease • The disease is endemic in Nigeria
ABSTRACT Schistosomiasis is a water-borne parasitic disease caused by schistosomes and transmitted by fully aquatic or amphibious freshwater snails in whose bodies the human-infective larvae, cercariae, develop. Adult schistosome worms colonise human blood vessels for years, successfully evading the immune system while excreting hundreds to thousands of eggs daily, which must either leave the body in excreta and/or urine or become trapped in nearby tissues. Trapped eggs induce a dist...
