Background/Aim Sorafenib has been the historical first-line treatment of choice for unresectable or metastatic hepatocellular carcinoma (HCC) since 2007. However, on May 29, 2020, FDA approved atezolizumab plus bevacizumab (AB) combination for HCC and gave it priority over sorafenib. Here, we performed a systematic review evaluating the efficacy and safety of combination immunogenic chemotherapy as first-line therapy as opposed to sorafenib (S) and atezolizumab (A) monotherapies.
Abstract BACKGROUND Despite the use of the current standard therapy, the prognosis of unresectable hepatocellular carcinoma (HCC) patients is poor, with median survival times of 40 mo in intermediate HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] and 6–8 mo in advanced HCC (BCLC stage C). Although patients with early-stage HCC are usually suitable for therapies with curative intention, up to 70% of patients may manifest disease relapses at 5-year surveillance. Within the past decade, t...
ABSTRACT Crude oil spillage is a big threat to the soil fertility. Spillage occurs due to the pipeline rupture, and traffic accidents involving tankers. An investigation was carried to assess the effects of crude oil spillage on the physicochemical properties of soil in Nnagi-Ama, Niger Delta Nigeria. For this purpose soil samples were collected in the Nnagi-Ama, tested in a laboratory, and compared to non-polluted (control) soil sample. The pH values of the soil samples remained almost t...
ABSTRACT Standard precautions are a set of infection control practices used to prevent transmission of diseases that can be acquired by contact with blood, body fluids and non-intact skin. An effective Infection Prevention and Control (IPC) program is fundamental to quality health care. This is because it has the potential benefits of reducing disease burden on health care workers, patients, health institutions and the nation as a whole. This study was conducted with the main objective of es...
CONTENTS GENERAL INFORMATION.. 3 Title of Study. 3 Project Supervisor. 3 Principal Investigator. 3 PROJECT DEFINITION.. 4 Definition of Terms. 4 Project Summary. 4 Research Question. 5 Objectives. 5 Anticipated ethical issues. 5 Rationale. 6 FINAL PROJECT OVERVIEW... 10 Food Safety. 10 The Codex Alimentarius. 11 Restaurant Food Safety. 12 UPDATED RESEARCH SUMMARY.. 14 Participating Businesses. 14 Demographics. 14 Food Safety Knowledge Test and Attitudes. 16 ...
Abstract The purpose of the study was to investigate the hypoglycemic effects of ethanolic and hexane extracts of Sonchus oleraceus in normal albino rats using fasting blood glucose and glucose tolerance tests. About 200 g leaves of S. oleraceus were macerated in 2 liters of hexane for two days, filtered and evaporated to dryness. Sixty albino rats were divided into six groups. Negative control group received water (5ml) and the positive control group administered by glibenclamide (5 mg/kg) w...
ABSTRACT Rapid diagnostic test kits are a crucial component of HIV diagnosis in resource limited settings. HIV RDTs are recommended because they are less expensive, require little expertise, require little sample volume and generate results in less than 20 minutes. The WHO, CDC, and UNAIDS recommend countries to undertake pre and post market evaluations of HIV RDTs used for HIV testing in that particular country. Little is known about post market evaluations of test used in Ghana. Most of th...
ABSTRACT The prevalence of childhood anaemia remains high in the Kintampo district despite various intervention programs adopted in the past to reduce it. A cross-sectional study investigating knowledge, attitudes, beliefs and practices was carried out among seventy randomly selected mothers to find out why childhood anaemia is still a major problem in the district. Data were also collected from six traditional healers who specialize in treating childhood diseases including anaemia. Analysis ...
ABSTRACT Background: Honey and table sugar are commonly used sweeteners by many consumers. These sweeteners are examples of disaccharide sugar which forms part of the complex macromolecule, carbohydrate. Excessive consumption of dietary sugars including table sugar and honey is associated with several metabolic abnormalities and adverse health conditions such as obesity, diabetes and cardiovascular disease. There is a general debate by many researchers and consumers that honey is better t...
ABSTRACT For over a decade now, adolescent sexual and reproductive health and more especially condom use, has increasingly been on national agendas. In many countries especially in Sub Saharan Africa, this concern has been driven by the high prevalence of HIV and AIDS among young people. Other driving forces of comparable magnitude have been the following; - 800 women died every day in 2013 due to pregnancy related causes. A chunk of it occurred in Sub – Saharan Africa (SSA). - One i...
ABSTRACT This study examined the implementation challenges of the Millennium Development Goal to improve maternal health in the Tamale Metropolis. The study used a qualitative descriptive study. Purposive sampling was used in the selection of participants for the study. The methods for data collection included in-depth interviews, focus group discussions and a review of documents. The study participants included midwives and health managers at the facility level. The study revealed that the ...
ABSTRACT Introduction: Globally, prematurity is a major determinant of neonatal morbidity and mortality contributing about 30%-40% of neonatal mortality and 20% to 30% of infant and under-five mortality. The world‟s preterm birth rate keeps rising since the last two decades with an increase of 20% since 1990 in high-income countries. Major risk factors remain unknown. The consequences are enormous with developmental and childhood complications as well as high economic and psycho-social bu...
ABSTRACT The study explored how childhood burns and falls are managed in the New Juaben Municipality in the Eastern Region of Ghana. This was against the background that childhood burns and fall-related injuries are major public health concerns that manifest in frequent hospitalization, high treatment cost, long period of recovery, pain, scar and disabilities. To address these concerns, the study set out to determine the risk factors for these childhood mishaps, to explore the treatment pra...
ABSTRACT BACKGROUND Globally, men play critical role in women‘s ability to seek health care, including maternal health care. Male partner involvement is a key factor that cannot be ignored in the quest for improvement in maternal health. Male participation has been shown to yield substantial influence in decisions and health outcomes in several other areas of maternal health care, including antenatal, labour and delivery and postnatal care. However, male involvement has been found to be a...
ABSTRACT Patient waiting time is the time interval between when a patient presents him/herself for health care services and when he/she finally leaves the health facilities. This project work examined the causes of patient waiting time in the outpatient department at the General Hospital Mokwa. Using simple random of twenty one questionnaires to elicit information from health record officer, physician and patient attending consultative outpatient department. The results obtained indicated t...