Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria

Background:  The  current  upsurge  in  the  use  of  polyherbal  remedies  and  coupled  with  loose  regulation  on  public access  to  these  products  underscore  research  efforts  to  evaluate  their  biochemical  effect,  noting  also  that  many  of  the polyherbal  medicines  lack  scientific  evidence  to  support  their  medicinal  claims.  Objective:  We  therefore  investigated  the potential  genotoxicity,  hematotoxicity  and  clastogenicity  of  three  commonly  consumed  polyherbal  formulations (OsomoBitters™,  Ogidiga™  and  BabyOku™)  in  South-West  Nigeria,  in  experimental  rats.  Methods:  Two  hundred  and  fifty (250)  adult  female  wistar  rats  were  randomly  selected  and  distributed  into  10  groups  of  25  rats  each.  Two  mL/kg  body  weight of  distilled  water,  a  non-alcoholic  non-polyherbal  formulation  (Fanta®),  a  polyherbal  non-alcoholic  formulation (YoyoBitters™)  and  an  alcoholic  non-polyherbal  drink  (Sabrina™)  were  orally  administered  to  the  control  groups  while BabyOku™,  OsomoBitters™  and  Ogidiga™  herbal  formulations  were  administered  to  the  experimental  groups  at  doses  of  2 mL/kg  and  3  mL/kg  body  weights.  Results:  A  dose-  and  tissue-dependent  increase  in  induction  of  apoptotic  DNA fragmentation  was  observed  in  the  polyherbal  groups  relative  to  control  groups.  Also,  an  increase  in  micronucleated polychromatic  erythrocytes  was  formed  in  a  dose-dependent  manner  in  the  polyherbal  groups  when  compared  with  the  control groups.  Conclusion:  From  our  findings,  polyherbal  formulations  may  possess  clastogenic,  hematotoxic  and  genotoxic potentials  in  rats.


Overall Rating

0

5 Star
(0)
4 Star
(0)
3 Star
(0)
2 Star
(0)
1 Star
(0)
APA

Somade, O. (2018). Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria. Afribary. Retrieved from https://tracking.afribary.com/works/potential-genotoxicity-hematotoxicity-and-clastogenicity-of-three-commonly-consumed-polyherbal-formulations-in-abeokuta-south-west-nigeria

MLA 8th

Somade, Oluwatobi "Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria" Afribary. Afribary, 27 Mar. 2018, https://tracking.afribary.com/works/potential-genotoxicity-hematotoxicity-and-clastogenicity-of-three-commonly-consumed-polyherbal-formulations-in-abeokuta-south-west-nigeria. Accessed 25 Nov. 2024.

MLA7

Somade, Oluwatobi . "Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria". Afribary, Afribary, 27 Mar. 2018. Web. 25 Nov. 2024. < https://tracking.afribary.com/works/potential-genotoxicity-hematotoxicity-and-clastogenicity-of-three-commonly-consumed-polyherbal-formulations-in-abeokuta-south-west-nigeria >.

Chicago

Somade, Oluwatobi . "Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria" Afribary (2018). Accessed November 25, 2024. https://tracking.afribary.com/works/potential-genotoxicity-hematotoxicity-and-clastogenicity-of-three-commonly-consumed-polyherbal-formulations-in-abeokuta-south-west-nigeria