Ethanolic extract of Jatropha gossypifolia exacerbates Potassium Bromate-induced clastogenicity, hepatotoxicity, and lipid peroxidation in rats
Extracts of J. gossypifolia L. have been reported to have several medicinal values, including potential anti-cancer and anti-inflammatory properties. In this study, we investigated the anti-clastogenic and hepatoprotective, effects of the ethanolic leaf extract of J. gossypifolia L. in potassium bromate (KBrO3)-induced toxicity in rats. The general trend of the results indicates significant increases (p
Brain, lung, and heart oxidative stress assessment of an overthe-counter pyrethroid insecticide product in Nigeria
We evaluated the brain, lung, and heart oxidative stress in rats exposed to aerosol of an over-thecounter pyrethroid insecticide product in Nigeria. The experimental animals were randomly divided into four groups: group I (control) was not exposed to the insecticide aerosol, while groups II, III, and IV were exposed to 6.0 mL m-3, 12.0 mL m-3, and 18 mL m-3 of insecticide ae...
Potential Genotoxicity, Hematotoxicity and Clastogenicity of Three Commonly Consumed Polyherbal Formulations in Abeokuta South-West Nigeria
Background: The current upsurge in the use of polyherbal remedies and coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting also that many of the polyherbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity, hematotoxicity and ...
Extra-pulmonary oxidative stress investigations of an over-the-counter pyrethroid insecticide product in rats
Extra-pulmonary oxidative stress investigations of exposure to aerosol, of an over-the-counter pyrethroid insecticide product in Nigeria in Wistar rats were carried out. Four groups of five animals each were used in this study, and were exposed to different concentrations of the insecticide aerosol. Malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined in the live...
Edible camphor-induced histopathological changes in hippocampus and cerebral cortex following oral administration into rats
Introduction: Raw edible camphor (EC), and as component of herbal infusions are widely used to treat pile, back pain, erectile dysfunction, and as an aphrodisiac especially in preparation for sexual intercourse by men. It has been traced in umbilical cord, blood, fetal, adipose, and other tissues including brain, where it bioaccumulates. Methods: The study, therefore, investigated the possible histopathological changes in brain, heart, and spleen that may result following ...
Induction of micronuclei in bone marrow cells and hepatotoxicity of one of the most common over-the-counter pyrethroid insecticide products in Nigeria
Increasing environmental pollution in the tropics is creating a breeding ground for mosquitoes, leading to increasingly frequent use of insecticides to combat home infestation of mosquitoes, the vector of malarial parasites. Household members are therefore more prone to aerosol exposure and subsequent health effects. We assessed the hepatotoxic and clastogenic effects in rats exposed to different levels of aerosols of one of the insecticides most commonly in used in Nigeria. There were signif...
ANTICLASTOGENIC AND HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS
Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. We therefore carried out this study to investigate the possible ameliorative effects of ginger against the clastogenicity, hepatotoxicity and oxidative stress induced by nitrobenzene (NB) administration in wistar rats. Twenty male wistar rats were divided into four g...
ROLE OF CIRCADIAN CLOCK GENES IN THE REGULATION OF CELL CYCLE PROCESSES
One interesting branch of biochemistry which scientists are still trying to completely unravel is the area of chronobiochemistry. The history of chronobiology is dated 400 B.C., when Androsthenes observes that leaves of certain trees open during the day and close at night. It was only recently that the first human clock gene was discovered. All living organisms possess an internal bio...
Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats_content_1
ABSTRACT Background: Edible camphor (EC) is one of the ingredients in the preparation of local infusion for the management and treatment of pile, back pain, and erectile dysfunction, which are practices commonly in the south-western part of Nigeria. Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal ...