Pathology Research Papers/Topics

The Role of a Minimum Immunohistochemical Antibody Panel in Confirming Undifferentiated Nasopharyngeal Carcinoma: A Cross-Sectional Study at the Muhimbili National Hospital, Dar-es-Salaam, Ta

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is a malignant epithelial neoplasm arising in the nasopharyngeal mucosa that shows light microscopic and/or ultrastructural evidence of squamous differentiation. Immunohistochemistry (IHC) can be used to reliably distinguish undifferentiated NPC from other malignant tumors, and the technique may be a necessary tool toward the arrival of a definitive diagnosis, particularly when dealing with challenging cases. Materials and Methods: This w...

Determination Of Plasma Levels Of Fibroblast Growth Factor 23 In Ghanaian Individuals With Hypertension And Chronic Kidney Disease

ABSTRACT Background: Fibroblast growth factor 23 (FGF23) is a newly found hormone that promotes renal phosphate excretion. It is secreted by osteocytes. In progressive chronic kidney disease (CKD), FGF23 levels increase in parallel with the deterioration of renal function, thus serves as a novel risk marker for progression of chronic kidney disease. The physiologic stimulus for FGF23 secretion is linked to hyperphosphatemia caused by phosphate load. Elevated FGF23 levels have spurious effect...

Clinical and Histopathological Profile of Patients with Prostate Cancer in Kampala

ABSTRACT Background: Prostate cancer (PCa) is the most prevalent malignancy among adult men with marked variation in mortality rate across regions globally. Uganda has the highest incidence of prostate cancer in East Africa. This study explored the spectrum of clinical and histopathological profile of patients diagnosed with PCa in Uganda between 2012 and 2014 at the Department of pathology, Makerere College of Health Sciences (MakCHS). Methods: This was a descriptive cross-sectional study ai...

Prognostic Factors For Overall Survival Of Patients With Prostate Cancer In Kyadondo County, Uganda

ABSTRACT Prostate cancer (PCa) is the leading cause of cancer morbidity and mortality in elderly men worldwide. It is the second and fih leading cause of cancer-related deaths among men in developing and developed countries respectively [1]. Globally, black men are more affected than whites. Miller et al. [2] reported the incidence rates of PCa for black American men and those from Asia particularly in India, was 228.7 and 141.0 per 100,000 respectively [3]. Uganda is one of the countries in ...

Primary Cutaneous Malignant Melanoma With Papillary Features: A Case Report Signifying Morphologic Diversity In Malignant Melanoma

Aim: The purpose of this work was to describe the way how primary cutaneous malignant melanoma can present with papillary features and hence mimicking malignant tumours which are commonly accompanied with papillary features such as papillary thyroid carcinoma. Presentation of Case: The case reported in this article was of an African female aged 61 years who presented with a darkish small swelling on the dorsum of the right hand, slightly painful and tender for 3 months since its onset. Disc...

Clinicopathological Findings Of Retinoblastoma: A 10-Year Experience From A Tertiary Hospital In Kampala, Uganda

Abstract *is was a cross-sectional analytical study which involved a total of 234 eyeball surgical specimens from 214 patients with histological diagnosis of RB at Mulago National Referral Hospital (MNH) in Kampala, Uganda, between 2006 and 2015. *e formalin-fixed embedded paraffin (FFEP) tissue blocks were retrieved and retrospectively studied at Makerere pathology laboratory. Fourteen (5.6%) cases were excluded from the study either because of missing tissue blocks or being spoiled by insec...

Cardiovascular Risk Factors In Premenopausal Women With Breast Cancer After Oophorectomy

ABSTRACT Oophorectomy is a management modality for Pre-Menopausal women with Breast Cancer (PMBC) resulting in reduced oestrogen levels and artificial menopause. Metabolic alterations occur during natural menopause while reduced levels of oestrogen (a known cardioprotective factor) may alter plasma lipids, lipoproteins and other cardiovascular risk factors. The effects of low estrogen levels, which occur in oophorectomised women are not known. This study was therefore designed to investigate ...

Combination of Reduced Levels of Serum Albumin and Αlpha-2-Macroglobulin Differentiates Newly Diagnosed Pulmonary Tuberculosis Patients from Patients on Chemotherapy

ABSTRACT: Pulmonary tuberculosis (PTB) is global disease affecting about one third of the world’s population with its attendant mortality and morbidity. Acute phase proteins have been used in monitoring the progression of infections but not in relation to PTB in this environment. The levels of total protein, albumin, α-2-macroglobulin, transferrin, and haptoglobulin were determined in 23 patients with PTB and 17- age / sex matched PTB-free controls using spectrophotometric and immunodiffus...

Antioxidant Status Of Sickle Cell Disease Children With And Without Malaria At The Korle-Bu Teaching Hospital

ABSTRACT Background Sickle cell disease (SCD) is a hereditary disorder prevalent in malaria endemic areas, in which there is state of chronic vasculopathy characterized by endothelial dysfunction, and increased oxidative stress. SCD patients with malaria may experience worse outcomes because malaria infection in SCD leads to depletion of antioxidants which may complicate the disease. Few studies, however, have evaluated the antioxidant status of SCD patients with discrete clinical syndromes. ...

Variations In Serum Testosterone Levels In Ghanaian Males

ABSTRACT The major objective o f this work was to establish serum testosterone levels in Ghanaian males, for use at the Korle-Bu Teaching hospital and to find out the variation with age, and at what age in an individual would hormonal supplementation be needed. The study was carried out using serum collected from a cross section of the children and adult population in Accra. The analysis was done using an EIA method with an assay sensitivity o f 0.05nmol/L. The results o f serum testosterone ...

Serum Leptin And C-Reactive Protein Levels In Obese Ghanaians With And Without Type 2 Diabetes Mellitus At Korle-Bu Teaching Hospital (Kbth), Accra

ABSTRACT The prevalence of obesity is increasing in Ghana. Obesity is associated with increased risk of many chronic diseases especially type 2 diabetes mellitus. Researching into diagnostic markers is very important. Leptin and C-reactive protein have been implicated in the pathogenesis of diabetes related disorders such as obesity. The aim of this study was to compare serum leptin and C-reactive proteins concentration in obese Ghanaians with and without type 2 diabetes mellitus. Eighty (80)...

Evaluation Of Antioxidant And Cytotoxic Properties Of Citrullus Lanatus Extracts

ABSTRACT INTRODUCTION Citrullus lanatus (watermelon) is well noted for its nutritional and therapeutic uses. The seeds and mesocarp of the fruit, which were of interest in this study are rich sources of phytochemicals including flavonoids and phenols. These bestow upon the fruit its medicinal properties such as antioxidant, anti-inflammatory, analgesic and anti-hypertensive activities. Cancer has been a public health menace for long and it currently stands as the world’s second killer disea...

Assessment Of The Viability Of Adult Onchocerca Volvulus In Tissue Sections Using Enzyme Histochemical Demonstration Of Lactate Dehydrogenase Activity

ABSTRACT Current methods of assessing the viability of adult Onchocerca volvulus in drug evaluations are mainly based on in-vitro and histological techniques. The in-vitro method is efficient in detecting live and dead worms while the histological method is more efficient in determining the number of worms in the nodules. Despite their capabilities in some areas, these techniques have certain methodical deficiencies which often lead to inaccurate interpretation of results or marked variations...

Levels Of Adipokines In Ghanaian Women In Jamestown, Accra

ABSTRACT Adipokines are bioactive mediators that communicate between adipose tissue and other biological systems. Adipokines have strongly been linked to adiposity and obesity. The body’s balance of adipokines is fundamental to prevent obesity and other noncommunicable disease. However, their levels in the aetiogenesis of obesity or otherwise have not been studied in Ghana.. The aim of the study was to investigate the levels of plasma Leptin, Adiponectin, Resistin (major adipokines) among...

Influence Of Religiosity, Sexual Attitudes And Sexual Sensation Seeking On Sociosexuality In Accra, Ghana

ABSTRACT Sociosexuality is a sexual risk behaviour, which poses public health concerns. This study aimed at determining some predictors of sociosexuality among young adults in Accra, Ghana. A sample size of 315 (164 = males, 151 = females) was recruited for this study. Participants completed questionnaires assessing dimensions of sociosexuality (i. e. sociosexual behaviour, sociosexual attitude, and sociosexual desire), sexual sensation seeking, sexual attitudes, dimensions of religiosity, a...


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