ABSTRACT Diabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves were g...
ABSTRACT This research was conducted to determine the concentrations of heavy metals and proximate composition of different cereals (maize, millet and rice). Two different samples each sold in two different markets (Ogbete and Gariki) in Enugu, were used for this work, using atomic, absorption spectrophotometer. The heavy metal screening of the cereal samples showed the presence of arsenic in the range of 0.456ppm-0.955ppm but was not detected in sample E and f which are the two different ric...
ABSTRACT Malaria is a significant public health problem in the world especially in in sub-Saharan Africa. One of the key contributory factors to the development and progression of malaria and its complications is oxidative stress, a condition characterized by increased production of free radicals or impaired antioxidant defence system. Glucose-6-phosphate dehydrogenase (G-6-PD) produces NADPH which intends regenerate reduced glutathione (GSH), an antioxidant which helps in the removal of free...
ABSTRACT Aim: This study is aimed at assessing the effect of Xylopia aethiopica fruit on the lipid profile of Wistar rats. Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State, Nigeria and were authenticated. They were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard met...
ABSTRACT Aim: This study is aimed at determining the effect of Xylopia aethiopica fruit on weight gain and blood sugar level of Wistar rats. Methodology: The fruits of Xylopia aethiopica were obtained from new market in Aba, Abia State, Nigeria and were authenticated. They were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard method. ...
ABSTRACT Background: The use of Xylopia aethiopica fruit in folklore medicine is on the increase without regard to its toxicity. Aim: This study was aimed at examining its toxicity on the kidney of Wistar rats. Methodology: The fruits of Xylopia aethiopica were air-dried and extracted using Soxhlet apparatus and ethanol as solvent. The median lethal dose (LD50) of the extract was determined using standard method....
INTRODUCTION: Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies ). This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response. A type of white blood cell, the B cell, produces antibodies that bind to the injected antigen. These antibody producing B-cells are then harvested from the mouse and, in turn, fused with immortal B cell cancer cells, a myeloma , to produce a hy...
ABSTRACT Plants have long been a source of nutrition and therapy to man. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action in the human body. This study evaluated the oxytocic potential of methanol extract of Sida acuta on female albino rats in vitro. Oxytocin was used as a standard drug though it is a biochemically synthesized hormone that act on distant hormone receptor to induce contractions. The methanol extract was prepared...
The aim of this study is to access the antihypertensivepotential of garlic juice in rats. To achieve this, 30 Wistar ratswere divided into three groups of 10 each. Rats in groups 1 and 2received aspecial prepared egg feed diet (24 egg yolkmixed with 1kg of normal rat diet) while those in group 3 received normalfeed diet and they served as the control group. Animals in group2 were administered 3 mL/100g body weight of undiluted garlicjuice simultaneously with the feeding. The animals were fedo...
Hypertension constitutes a major risk factor forseveral cardiovascular diseases such asatherosclerosis, heart failure, renal insufficiency,coronary artery disease and stroke. The risk factorincreases with age in both sexes. According to WHO,about one-third of the world’s population suffersfrom hypertension and the incidence has beenincreasing at a rapid rate due to life stylemodification. This study is aimed at investigating theeffect of egg yolk on blood pressure of Wistar rats. Toachieve ...
Aim: This study focuses on the effect of consumption of garri processed by traditional and instantmechanical methods on the lipid profile of Wistar rats.Methods: Cassava samples were obtained from the International Institute of Tropical Agriculture(IITA), Ibadan and were processed using traditional and instant mechanical methods. Fifteen adultmale Wistar rats were purchased from the Animal Holding Unit of the Department of Physiology,University of Ibadan, Nigeria with body weight between 100 ...
Recently, the use of ‘sunlight’ air freshener in Nigeria is on the increase. Some people use airfreshener in the office, car as well as in their homes, thereby constantly being exposed to it withoutconsideration of its adverse effect on human health. This study is therefore aimed at assessing theeffect of “sunlight” air freshener on oxidative stress biomarkers. Thirty (30) Wistar rats were dividedinto three groups of ten each and kept in different rooms. Rats in group 1 were not expos...
Background: The use of household insecticides for the eradication of insects especially mosquitoesin Nigeria is increasing. These insecticides are used without consideration of their adverse effect onhuman health.Aim: This study was aimed at accessing the effect of common household insecticides used inNigeria on male reproductive hormones of Wistar rats.Methodology: Thirty male Wistar rats were divided into five groups of six each and kept in differentrooms. Rats in group 1 were exposed to Ra...
Background: The need for fertility stimulation in men and women cannot be overemphasizedespecially when a marriage is childless in some communities in Nigeria. While chemical methodsfor fertility stimulation may have some side effects and are not readily available, remedy fromnatural sources can be used.Aim: This present study is aimed to evaluate the effect of coconut water on fertility in male Wistarrats.Materials and Methods: Coconuts of about 8 months old were harvested from Apata area of...
Background: The use of household insecticides for the eradication of insects especiallymosquitoes in Nigeria is increasing. These insecticides are used without consideration of theiradverse effect on human health.Aim: This study is therefore sought to investigate the effect of common household insecticidesused in Nigeria on oxidative stress biomarkers.Methodology: Thirty (30) male Wistar rats were divided into five groups of six (6) each. Rats ingroup 1 were exposed to Rambo, those in group 2...