Objective: To determine the noxious attribute of methanol extract of Nigeria bee propolis at 300 and 600 mg/kg body weight in rats. Methods: Healthy Wistar rats were indiscriminately assigned into three groups (A-C) of five rats each. The control rats (Group A) were orally given 0.5 mL of dimethyl sulfoxide daily for 21 days while rats in Groups B and C were administered the same 0.5 mL dimethyl sulfoxide containing 300 and 600 mg/kg body weight methanol extract of bee propolis respective...
Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome ...
Te study aims to determine the association of malaria infection with ABO blood groups and genotype and also to detect point mutations at positions 86, 184, 1034, and 1042 of the Plasmodium falciparum multidrug resistance gene (pfmdr1) in blood samples collected from pregnant women attending General Hospital Minna. Out of 250 pregnant women screened, 39 (15.60%) had malaria infection. Prevalence was higher in women, during the third trimester (46.15%), genotype AA (64.10%), and O blood group (...
Abstract The enhanced safe drug delivery properties of polyethylene glycol (PEG) – modified Diaminazene aceturate nanocomposite against Trypanosoma brucei infected rats were evaluated. The drug conjugation was carried out by adding gold nanoparticle to PEG and diminazene aceturate. A group of infected rats were treated with free diaminazene aceturate, while other groups were treated with conjugated drug at different drug release time interval. Results revealed complete parasite clear...
Abstract Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. KV was administered at a dose of 100...
Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcumalonga and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats.Place and Duration of Study: This research was carried out in Ibadan Nigeria betweenNovember 2017 and January, 2018.Methods: Fifty (50) healthy male albino rats with body weights between 150 and 200 g were usedfor this study. They were randomly divided into ten groups of five rats each. Group I was administered...
Aim: This study is aimed at investigating the hepatoprotective effect of Parkia biglobosa on acuteethanol-induced oxidative stress in wistar rats.Methods: P. biglobosa was purchased from a local market at Orita-Challenge area of Ibadan,Nigeria. They were sun dried and milled into powder using an electronic blender (Moulinex). Thepowder was extracted using n-hexane. Twenty adult male wistar rats with body weight between120 and 150 g were purchased from the Central Animal House, College of Medi...
Aim: The aim of this study is to evaluate the nutritional and anti-nutritional composition of garriprocessed by traditional and instant mechanical methods.Place and Duration of Study: This study was carried out in Achara, Uturu and analyses weredone at the Biochemistry and Central Laboratories of Gregory University, Uturu, Abia Statebetween March and July, 2017.Methods: Cassava was harvested and processed in Achara area of Uturu, Abia State. For garriprocessed by instant mechanical method, ca...
Rhodanese, a cyanide detoxifying enzyme, was isolated and partially purified from malted maize (Zea mays) using 85% ammonium sulphate precipitation and ion-exchange chromatography on CM- Sephadex C-25. The specific activity of the enzyme obtained was 5.07RU/mg protein with a yield of 9.6% and purification fold of 2.13. The Michaelis constant (Km) values of the substrates sodium thiolsulphate (Na2S2O3) and potassium cyanide (KCN) were 80 mM and 300mM while their Vmax were 4.86 RU/ml/mi...
ABSTRACT Evidences have implicated free radicals or reactive oxygen species in mercuric chloride-induced nephrotoxicity. Diphenyl diselenide (PhSe)2, a simple and stable organoselenium compound, has been proposed as a good candidate for pharmacological and therapeutic purposes. This particular study was designed to investigate the protective effect of (PhSe)2 against mercuric chloride-induced nephrotoxicity. In this study, 44 female Wistar rats with weights ranging from 125g and 180g were...
Activation of caspase 3&9 by methanol extract of Gloriosa superba ABSTRACT Mitochondrion is the key regulator in cellular energy homeostasis and plays a central role in determining cell apoptotic process; it is therefore regarded as a vital target for cancer chemotherapy. Cancer is obviously one of the most common areas where demand for alternative treatment is overwhelming. Many investigations revealed that bioactive compounds in natural products can act on mitochondria to trigger the per...
Methanol extract of Gloriosa superba in this research was adopted due to the presence of photochemicals present in the plant. This photochemicals are known to act as antioxidants and anti tumor agent but it is not yet known if the activity of the plant is through the mitochondria mediated pathway, caspase activation and induction of apoptosis where up regulation is necessary
Background: African locust bean is a condiment believed to be for the people of low class. Itshealth importance has not been fully known especially to the so-called high class.Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar andlipid profile of albino rats.Methods: African locust bean (ALB) was purchased from a local market at Orita-Challenge area ofIbadan, Nigeria. They were sun dried and milled into powder using an electronic blender. Thepow...
The use of seasonings to enhance the flavor of food has been on the increase in recent time. Different types of seasonings are produced daily. Theconstituent of these flavor-enhancers is unknown to ignorant consumers. They only want to eat food with good taste without consideration of theeffect of these additives on their health. These seasonings contain monosodium glutamate (MSG) which really spiced the food. This review focuses onthe toxicological effect of monosodium glutamate in seasoning...
Background: Access to potable water has become a difficult task in many countries of the worldincluding Nigeria. In Nigeria, the government is trying her best to make water supply available tothe masses but till now this vision has never been accomplished. If those living in urban areascould not have access to portable water supply by the government, what is the fate of the peopleliving in rural areas? This has led to increased usage of sachet and bottled water as portabledrinking water.Aim: ...