Biochemistry Research Papers/Topics

EFFECT OF CELLGEVITY ON CATALASE ACTIVITY OF RAT MODEL OF PARKINSON DISEASE

Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating the impact o...

Effect of Emilia Sonchifolia on Globulin and Bilirubin level of Winter rat

ABSTRACT  The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifo...

FERTILITY ENHANCING POTENTIAL AND METABOLIC EFFECT OF ETHANOLIC ROOT EXTRACT OF SPHENOCENTRUM JOLLYANUM IN MALE WISTAR RATS

The overall objective of this study is to scientifically evaluate the claimed fertility enhancing potential and to assess the metabolic effect of the ethanolic extract of  Sphenocentrum jollyanum pierre (Menispermaceae) root using male wistar rats as model. The specific objectives include the following ·         To determine the proximate and phytochemical composition of the ethanolic extract of Sphenocentrum jollyanum  (root) this will justify the ethno pharmacological  use of th...

EFFECT OF SWIMMING TRAINING ON COGNITIVE FUNCTION IN SCOPOLAMINE INDUCED DEMENTIA IN MICE.

ABSTRACT The present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on ...

Evaluation of Nutritional and Anti-nutritional Compositions of Leaves of Gingko biloba (Maiden Hair) Tree Found in Nigeria.

ABSTRACT Ginkgo biloba (GB) leaves and extracts have been recognized worldwide for its renowned nutritional and medicinal properties. GB tree is highly grown and used in Asian and South American countries unlike Nigeria. In this study, we examined the nutritional and anti-nutritional compositions of GB leaves (whole dried, and aqueous and ethanol extracts) grown in Nigeria. Association of Official Analytical Chemists (AOAC) method was used to determine the proximate and vitamin compositions w...

In Vitro Antioxidant Activity and Nitric Oxide Scavenging Activity on Citrullus Lanatus Seeds

Citrullus lanatus (water melon) is a commonly consumed fruit worldwide. The seeds are often thrown away without considering its potential nutritional and medicinal benefits. In this study, a methanol extract of citrullus lanatus seeds was analyzed for the presence of bioactive secondary metabolites and to determine its ability to scavenge 2, 2‐ diphenyl ‐1‐ picrylhydrazyl (DPPH.) radical, superoxide anion radical (O2.‐), and nitric oxide radical (NO.). Quantitative phytochemical a...

Molecular Docking and Structure Based Drug Design

Docking is a structure-based technique which attempts to find the “best” match, between two molecules. Molecular docking can be thought of as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.). The explosion of structural informatics, genomics and proteomic plays a major role in leading t...

NUTRITIONAL AND ANTI-NUTRITIONAL CONTENTS OF INGREDIENTS USED IN PREPARING GRANULATED DUMPLING (DAMBU)

ABSTRACT Nutritional and antinutritional content of ingredient used in preparing dambu were determined by proximate composition, vitamins, minerals and antinutritional contents analysis. Maize and Moringa flowers were used as the experimental samples and the work was conducted in triplicate which resulted in obtaining the experimental result in mean and standard deviation. Appreciable amount of nutritive composition were obtain in the used maize and Moringa samples. While the antinutritional...

KIDNEY FUNCTION PARAMETERS F PLASMODIUM PASSAGED MICE TREATED WITH CRUDE METHANOLEXTRACT OF AZADIRACHTA INDICA (NEEM)

ABSTRACT  Kidney function parameters were evaluated in plasmodium berghei infected mice treated with crude methanol extracts of Azadirachta indica leaves in this study. A total of  forty (40) male albino mice inoculated with quinine resistant strains of plasmodium berghei were randomized into nine (9) groups of (4) animals each while four additional mice serve as the uninfected control group. Group 1 was treated with tween 80, group 2 treated with 10mg/kg chloroquine while groups 3,4, and 5...

Effects of White Grub Extracts on Serum Glucose and Lipid Profile of Alloxan Induced Diabetes in Rats

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with an absolute or relative deficiency in insulin secretion or insulin action. To investigate the effect of white grub extract on alloxan-induced diabetic rats. Diabetes was induced in rats after 18 hours of fasting intraperitoneally by alloxan (80 mg/kg). A total of 40 rats used, were divided into eight groups (G1- GVIII) of five rats each. GII-GVIII...

Consumption of green tea (Camellia sinensis)

ABSTRACT Consumption of green tea (Camellia sinensis) may provide protection against chronic diseases, including cancer. Green tea polyphenols are believed to be responsible for this cancer preventive effect, and the antioxidant activity of the green tea polyphenols has been implicated as a potential mechanism. This hypothesis has been difficult to study in vivo due to metabolism of these compounds and poor understanding of the redox environment in vivo. Green tea polyphenols can be direct an...

Therapeutic Effect of Methanolic Extract of Telfairia occidentalis Leaves against Ethanol-Induced Oxidative Stress in Wistar Rats

This study sought to investigate the therapeutic effectof methanolic extract of Telfairia occidentalis leavesagainst acute ethanol-induced oxidative stress inWistar rats. Fresh plants of T. occidentalis werepurchased from Oja-Oba Market in Ibadan. Theleaves were dried and extracted using soxhletapparatus and methanol as the solvent. The methanolwas evaporated in a rotary evaporator at 35 oC witha yield of 2.31g representing a percentage yield of9.24%. Twenty adult male Wistar rats were used f...

Antihaemolytic Effect of Ethanolic Leaf Extract of Vernonia amygdalina in Wistar Rats

Antihaemolytic effect of ethanolic leaf extract ofVernonia amygdalina in Wistar rats is the aim of thisstudy. Fresh plants of V. amygdalina were harvestedfrom the Institute of Agricultural Research andTraining, Ibadan. The leaves were carefully removedfrom the stem and washed in running water toremove contaminants. They were air dried at roomtemperature in an open laboratory space for 14 daysand milled into powder. The extraction was doneusing soxhlet apparatus and ethanol as the solvent.Etha...

Preventive and Therapeutic Activities of Methanolic Extract of Talinum triangulare Leaves against Ethanol-Induced Oxidative Stress in Wistar Rats

Preventive and therapeutic activities of methanolicextract of Talinum triangulare leaves againstethanol-induced oxidative stress in wistar rats is theaim of this study. Fresh plants of T. triangulare werepurchased at a local market in Orita-Challenge,Ibadan. The leaves were dried and extracted usingsoxhlet apparatus and methanol as the solvent. Themethanol was evaporated in a rotary evaporator at35 oC with a yield of 2.76 g which represents apercentage yield of 11.04%. Twenty Wistar rats with...

Antioxidant Defense System in a Germinating P.Vulgaris

Phaseolus vulgaris, Common Bean is a herbaceous annual plant grown worldwide for its edible dry seed (known as just "beans") or unripe fruit (green beans) and a member of the legume family Fabaceae.  They are quite popular amongst the natives because of its high protein, minerals and vitamins content (Gentry et al., 1999). The use of a wide range of chemicals to destroy pests and weeds is an important aspect of agricultural practice in both developed and developing countries but there is a w...


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